Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. (Q46623064)

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6 January 2020

title

Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice (English)

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1

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author name string

Mohamed Qatanani

2

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6 January 2020

Anne Laure Sberna

3

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Rui Xiao

4

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6 January 2020

Jean Paul Pais de Barros

5

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6 January 2020

Jacques Grober

6

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6 January 2020

Valerie Deckert

7

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Anne Athias

8

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6 January 2020

Philippe Gambert

9

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Laurent Lagrost

10

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David D Moore

11

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Mahfoud Assem

12

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publication date

27 April 2008

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Journal of Lipid Research

6 January 2020

published in

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volume

49

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issue

8

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6 January 2020

page(s)

1682-1691

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PXR, CAR and drug metabolism

6 January 2020

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Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

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CAR, the continuously advancing receptor, in drug metabolism and disease

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Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

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Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

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Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood

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The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29.

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Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

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Key structural features of ligands for activation of human pregnane X receptor.

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A prospective, randomized trial of phenytoin in nonepileptic subjects with reduced HDL cholesterol.

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

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Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses

21 January 2018

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

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Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice.

21 January 2018

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Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice

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Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI.

21 January 2018

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Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

21 January 2018

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Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

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The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

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A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

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Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

21 January 2018

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

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Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.

21 January 2018

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Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

21 January 2018

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Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

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21 January 2018

Identifiers

DOI

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6 January 2020

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