High-altitude adaptation in humans: from genomics to integrative physiology (Q46659572)

24 December 2017

title

High-altitude adaptation in humans: from genomics to integrative physiology (English)

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24 December 2017

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6

Vineet Bafna

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24 December 2017

Priti Azad

1

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24 December 2017

Tsering Stobdan

2

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24 December 2017

Dan Zhou

3

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24 December 2017

Iain Hartley

4

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24 December 2017

Ali Akbari

5

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24 December 2017

Gabriel G Haddad

7

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24 December 2017

publication date

26 September 2017

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24 December 2017

Journal of Molecular Medicine

published in

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24 December 2017

volume

95

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24 December 2017

issue

12

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24 December 2017

page(s)

1269-1282

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24 December 2017

https://scigraph.springernature.com/pub.10.1007/s00109-017-1584-7

exact match

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cites work

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Tissue hypoxia during ischemic stroke: adaptive clues from hypoxia-tolerant animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Hypoxia tolerance in mammalian heterotherms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Tolerance to low O2: lessons from invertebrate genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Andean, Tibetan, and Ethiopian patterns of adaptation to high-altitude hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Cerebral Edema in Chronic Mountain Sickness: a New Finding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Acetazolamide: a treatment for chronic mountain sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Prevalence of Chronic Mountain Sickness in high altitude districts of Himachal Pradesh

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Consensus statement on chronic and subacute high altitude diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Peopling the Tibetan plateau: insights from archaeology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Altitude Adaptation: A Glimpse Through Various Lenses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Paleoindian settlement of the high-altitude Peruvian Andes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

An Ethiopian pattern of human adaptation to high-altitude hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Two routes to functional adaptation: Tibetan and Andean high-altitude natives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

The genetic basis of chronic mountain sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Human genetic adaptation to high altitude

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Pulmonary hypertension and chronic mountain sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Medicine at high altitude.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Sequencing of 50 human exomes reveals adaptation to high altitude

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Human high-altitude adaptation: forward genetics meets the HIF pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

The Andean adaptive toolkit to counteract high altitude maladaptation: genome-wide and phenotypic analysis of the Collas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

A novel candidate region for genetic adaptation to high altitude in Andean populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

A genetic mechanism for Tibetan high-altitude adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

On the origin of Tibetans and their genetic basis in adapting high-altitude environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

A genome-wide search for signals of high-altitude adaptation in Tibetans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Long-term genetic stability and a high-altitude East Asian origin for the peoples of the high valleys of the Himalayan arc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Interaction of CARD14, SENP1 and VEGFA polymorphisms on susceptibility to high altitude polycythemia in the Han Chinese population at the Qinghai-Tibetan Plateau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

A preliminary study of copy number variation in Tibetans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

The genetic architecture of adaptations to high altitude in Ethiopia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic adaptation to high altitude in the Ethiopian highlands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Novel genomic signals of recent selection in an Ethiopian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Investigating human disease using stem cell models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic evidence for high-altitude adaptation in Tibet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic signatures of high-altitude adaptation in Tibetans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Gene expression in chronic high altitude diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Widespread signals of convergent adaptation to high altitude in Asia and america

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Erythropoietin as an antiapoptotic, tissue-protective cytokine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Vascular endothelial growth factor: much more than an angiogenesis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Frequency spectrum neutrality tests: one for all and all for one.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Hypoxic regulation of erythropoiesis and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Hemoglobin research and the origins of molecular medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Susceptibility to high altitude pulmonary oedema: role of ACE and ET-1 polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

High altitude adaptation: genetic perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Pulmonary nitric oxide in mountain dwellers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Bosentan reduces pulmonary artery pressure in high altitude residents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: a prospective randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

The interdependence of endothelin-1 and calcium: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

A methylation assay for the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences in voided urine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Effects of the endothelin receptor antagonist bosentan on cardiac performance during porcine endotoxin shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Genetic selection by high altitude: Beware of experiments at ambient conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Direct measurement of local oxygen concentration in the bone marrow of live animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Sirtuin deacetylases as therapeutic targets in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Environmental stressors and the epigenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Developmental adaptation: where we go from here

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Pathophysiology and epidemiology of chronic mountain sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Adaptation to High Altitude: Phenotypes and Genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Physiological adaptation of the cardiovascular system to high altitude

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Polymorphisms of renin--angiotensin system genes as a risk factor for high-altitude pulmonary oedema

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

Effect of Blood-letting on Chronic Mountain Sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-017-1584-7

HIF-1 and human disease: one highly involved factor

21 January 2018

1 reference

12 December 2020

Impact of Oxygen Levels on Human Hematopoietic Stem and Progenitor Cell Expansion

1 reference

12 December 2020

Erythropoietin and the polycythemia of high-altitude dwellers

1 reference

12 December 2020

Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer

1 reference

12 December 2020

beta-Adrenergic dilator effects in consecutive vascular sections of skeletal muscle

1 reference

12 December 2020

Genetic association analysis of chronic mountain sickness in an Andean high-altitude population

1 reference

12 December 2020

Increasing prevalence of excessive erythrocytosis with age among healthy high-altitude miners

1 reference

12 December 2020

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

12 December 2020

Chronic mountain sickness

1 reference

12 December 2020

Gene expression, autonomic function and chronic hypoxia:lessons from the Andes

1 reference

12 December 2020

Inhaled nitric oxide for high-altitude pulmonary edema

1 reference

12 December 2020

Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara

1 reference

12 December 2020

Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.

1 reference

12 December 2020

Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice.

1 reference

12 December 2020

Mechanisms of cell survival in hypoxia and hypothermia

1 reference

12 December 2020

Up-regulation of endothelin-B receptors in atherosclerotic human coronary arteries

1 reference

12 December 2020

10.1007/S00109-017-1584-7

Identifiers

DOI

1 reference

24 December 2017

1 reference

24 December 2017