Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. (Q46661965)

24 December 2017

title

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. (English)

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24 December 2017

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4

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author name string

Huazhang An

1

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24 December 2017

Jin Hou

2

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24 December 2017

Jun Zhou

3

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24 December 2017

Hongmei Xu

5

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24 December 2017

Yuejuan Zheng

6

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24 December 2017

Yizhi Yu

7

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24 December 2017

Shuxun Liu

8

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24 December 2017

Xuetao Cao

9

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24 December 2017

language of work or name

English

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publication date

6 April 2008

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24 December 2017

published in

Nature Immunology

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24 December 2017

volume

9

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issue

5

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24 December 2017

page(s)

542-550

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24 December 2017

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Negative regulation of toll-like receptor-mediated immune responses

21 January 2018

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

21 January 2018

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 January 2018

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

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Autoimmunity through cytokine-induced dendritic cell activation

21 January 2018

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SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

21 January 2018

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Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling

21 January 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

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Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages

21 January 2018

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

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IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

21 January 2018

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Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

21 January 2018

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Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

21 January 2018

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Dual receptors and distinct pathways mediate interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide. Involvement of CD14/TLR4, CR3, and phosphatidylinositol 3-kinase

21 January 2018

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IRAK: a kinase associated with the interleukin-1 receptor

21 January 2018

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Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling

21 January 2018

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SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei

21 January 2018

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Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B.

21 January 2018

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

21 January 2018

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FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction

21 January 2018

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IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression

21 January 2018

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Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

21 January 2018

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Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis

21 January 2018

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The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

21 January 2018

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Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

21 January 2018

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Toll-like receptor signaling pathways

21 January 2018

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7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

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7 January 2021

Tyrosine kinase Syk associates with toll-like receptor 4 and regulates signaling in human monocytic cells

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7 January 2021

Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells

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7 January 2021

Identifiers

DOI

10.1038/NI.1604

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24 December 2017

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24 December 2017