Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production. (Q46684542)

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English	Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production.	scientific article

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18363826

Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6314489&resulttype=core&format=json

13 May 2020

James A Windelborn

1

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13 May 2020

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Peter Lipton

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13 May 2020

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1 July 2008

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24 December 2017

http://europepmc.org/abstract/MED/18363826

Journal of Neurochemistry

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13 May 2020

106

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13 May 2020

1

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13 May 2020

56-69

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13 May 2020

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based on heuristic

inferred from PubMed Central ID database lookup

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Phospholipase A2 mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Inhibition of proteolysis by a cyclooxygenase inhibitor, indomethacin

1 reference

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21 January 2018

UVA/B-induced apoptosis in human melanocytes involves translocation of cathepsins and Bcl-2 family members

1 reference

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Oxidative neuronal injury. The dark side of ERK1/2.

1 reference

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21 January 2018

The lysosome turns fifty

1 reference

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21 January 2018

N-methyl-D-aspartate receptor activation and Ca2+ account for poor pyramidal cell structure in hippocampal slices.

1 reference

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21 January 2018

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

1 reference

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21 January 2018

Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.

1 reference

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Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2.

1 reference

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Cell death by necrosis: towards a molecular definition

1 reference

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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

1 reference

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Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia

1 reference

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Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Changes in the concentrations of cerebral proteins following occlusion of the middle cerebral artery in rats

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

1 reference

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21 January 2018

Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Neuroprotective effects of glutamate antagonists and extracellular acidity

1 reference

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21 January 2018

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

1 reference

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21 January 2018

PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

1 reference

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21 January 2018

Intralysosomal iron chelation protects against oxidative stress-induced cellular damage.

1 reference

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21 January 2018

Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia

1 reference

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21 January 2018

Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

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An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis

1 reference

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Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Intraischaemic hypothermia reduces free radical production and protects against ischaemic insults in cultured hippocampal slices

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1)

1 reference

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21 January 2018

In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

NR2B subunit exerts a critical role in postischemic synaptic plasticity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

In vitro ischemia and protein synthesis in the rat hippocampal slice: the role of calcium and NMDA receptor activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Phospholipid peroxidation induces cytosolic phospholipase A2 activity: membrane effects versus enzyme phosphorylation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

The phospholipase A2 superfamily and its group numbering system

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Cytosolic phospholipase A(2) alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Identification of sites of mannose 6-phosphorylation on lysosomal proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Differential hydroxylation of salicylate in core and penumbra regions during focal reversible cerebral ischemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

A model of global cerebral ischemia in C57 BL/6 mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

H2O2-mediated damage to lysosomal membranes of J-774 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Irreversible aggregation of protein synthesis machinery after focal brain ischemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Delayed oxidant-induced cell death involves activation of phospholipase A2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Necrotic death as a cell fate

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05349.X

21 January 2018

Cytosolic Ca2+ changes during in vitro ischemia in rat hippocampal slices: major roles for glutamate and Na+-dependent Ca2+ release from mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemic cell death in brain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals are involved in the damage to protein synthesis after anoxia/aglycemia and NMDA exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor-mediated arachidonic acid release in neurons: role in signal transduction and pathological aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in cytosolic phospholipase A2 are less susceptible to cerebral ischemia/reperfusion injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of arachidonic acid on the lysosomal ion permeability and osmotic stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of neurofilament protein in cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal enzyme leakage during the hypoxanthine/xanthine oxidase reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of human cathepsin D in lysosomes in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed neuronal death in the rat hippocampus following transient forebrain ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal relationship of free radical-induced lipid peroxidation and loss of latent enzyme activity in highly enriched hepatic lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pairing the cholinergic agonist carbachol with patterned Schaffer collateral stimulation initiates protein synthesis in hippocampal CA1 pyramidal cell dendrites via a muscarinic, NMDA-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability properties of rat renal lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B and middle cerebral artery occlusion in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1471-4159.2008.05349.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6314489&resulttype=core&format=json

13 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6314489&resulttype=core&format=json

13 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6314489&resulttype=core&format=json

13 May 2020

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