Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts (Q46686110)

24 December 2017

title

Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts (English)

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24 December 2017

author name string

Burhan I Ghanayem

1

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24 December 2017

L Patrice McDaniel

2

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24 December 2017

Mona I Churchwell

3

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Nathan C Twaddle

4

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Rodney Snyder

5

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24 December 2017

Timothy R Fennell

6

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Daniel R Doerge

7

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24 December 2017

publication date

1 September 2005

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24 December 2017

published in

Toxicological Sciences

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24 December 2017

volume

88

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issue

2

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page(s)

311-318

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Determination of hemoglobin adducts in humans occupationally exposed to acrylamide

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Comparison of the hemoglobin adducts formed by administration of N-methylolacrylamide and acrylamide to rats.

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DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.

21 January 2018

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Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect

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Using cytochrome P-450 gene knock-out mice to study chemical metabolism, toxicity, and carcinogenicity

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21 January 2018

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Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice

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Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice

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21 January 2018

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Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine

21 January 2018

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Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide.

21 January 2018

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"IARC Group 2B carcinogens" reported in cigarette mainstream smoke.

21 January 2018

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Acrylamide: a comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure.

21 January 2018

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Analysis of acrylamide, a carcinogen formed in heated foodstuffs

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFI307

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24 December 2017

PubMed ID

16141435

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24 December 2017