Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. (Q46719881)

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scientific article published on 4 June 2015

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English	Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.	scientific article published on 4 June 2015

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scholarly article

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16 February 2020

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver (English)

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16 February 2020

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9

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16 February 2020

author name string

Sana Raza-Iqbal

1

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16 February 2020

Toshiya Tanaka

2

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16 February 2020

Motonobu Anai

3

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16 February 2020

Takeshi Inagaki

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16 February 2020

Yoshihiro Matsumura

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16 February 2020

Kaori Ikeda

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16 February 2020

Akashi Taguchi

7

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16 February 2020

Frank J Gonzalez

8

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16 February 2020

Tatsuhiko Kodama

10

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publication date

4 June 2015

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16 February 2020

Journal of Atherosclerosis and Thrombosis

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16 February 2020

22

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754-772

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16 February 2020

8

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16 February 2020

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator activated receptor-alpha expression in human liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF-21 as a novel metabolic regulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome biogenesis disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrates after the FIELD study: Some answers, more questions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and metabolic disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARalpha is a key regulator of hepatic FGF21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the importance of aminopeptidase A in hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional activation of Cidec by PPARgamma2 in adipocyte.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannose-binding lectin and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor alpha (PPARalpha) stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor α in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II drug metabolizing enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pr

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective peroxisome proliferator-activated receptor α modulators (SPPARMα): the next generation of peroxisome proliferator-activated receptor α-agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARalpha regulates the production of serum Vanin-1 by liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of peroxisomal lipid metabolism: the role of acyl-CoA and coenzyme A metabolizing enzymes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of hepatic VLDLR via PPARα is required for the triglyceride-lowering effect of fenofibrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrated physiology and systems biology of PPARα

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARβ/δ activation of CD300a controls intestinal immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-binding cassette transporter A1: key player in cardiovascular and metabolic disease at local and systemic level

1 reference

https://pubmed.ncbi.nlm.nih.gov/26040752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.5551/JAT.28720

1 reference

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16 February 2020

0 references

1 reference

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16 February 2020

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