A pH-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, StAR. (Q46742985)

24 December 2017

title

A pH-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, StAR. (English)

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24 December 2017

author name string

Bo Y Baker

series ordinal

1

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24 December 2017

Dustin C Yaworsky

series ordinal

2

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24 December 2017

Walter L Miller

series ordinal

3

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24 December 2017

language of work or name

English

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publication date

18 October 2005

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24 December 2017

Journal of Biological Chemistry

published in

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24 December 2017

volume

280

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24 December 2017

issue

50

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24 December 2017

page(s)

41753-41760

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24 December 2017

Molecular pathology and mechanism of action of the steroidogenic acute regulatory protein, StAR.

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Structure and lipid transport mechanism of a StAR-related domain

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Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

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Insights into steroidogenic acute regulatory protein (StAR)-dependent cholesterol transfer in mitochondria: evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR.

21 January 2018

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pH-dependent Interactions of the carboxyl-terminal helix of steroidogenic acute regulatory protein with synthetic membranes

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The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6

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Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells

21 January 2018

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Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action

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The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis.

21 January 2018

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Binding of steroidogenic acute regulatory protein to synthetic membranes suggests an active molten globule

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Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

21 January 2018

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The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule

21 January 2018

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Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic Acute Regulatory (StAR) protein

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Estimation of globular protein secondary structure from circular dichroism

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MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas

21 January 2018

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MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis

21 January 2018

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N-218 MLN64, a protein with StAR-like steroidogenic activity, is folded and cleaved similarly to StAR.

21 January 2018

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Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics

21 January 2018

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Steroidogenic acute regulatory protein (StAR) is a sterol transfer protein

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Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria

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21 January 2018

Identifiers

DOI

10.1074/JBC.M510241200

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24 December 2017

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24 December 2017