Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease. (Q46843633)

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English	Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.	scientific article

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scholarly article

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/16339026

Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease (English)

1 reference

Europe PubMed Central

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12 May 2020

Alzheimer's disease

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author name string

Michael T Maloney

1

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12 May 2020

Laurie S Minamide

2

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12 May 2020

Andrew W Kinley

3

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12 May 2020

Judith A Boyle

4

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12 May 2020

James R Bamburg

5

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12 May 2020

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publication date

1 December 2005

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/16339026

Journal of Neuroscience

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12 May 2020

25

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12 May 2020

49

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12 May 2020

11313-11321

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725891&resulttype=core&format=json

12 May 2020

Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in neurite outgrowth mediated by overexpression of actin depolymerizing factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins induce death of hippocampal neurons via the p75 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADF/cofilin and actin dynamics in disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actin-ATP hydrolysis is a major energy drain for neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Culturing hippocampal and cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-assembly of Abeta(1-42) into globular neurotoxins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down syndrome and beta-amyloid deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways towards and away from Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cofilin-like protein is involved in the regulation of actin assembly in developing skeletal muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated hippocampal neurons in cryopreserved long-term cultures: development of neuroarchitecture and sensitivity to NMDA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An electron microscopic study of the development of axons and dendrites by hippocampal neurons in culture. I. Cells which develop without intercellular contacts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta amyloidosis in Alzheimerʼs disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the beta-amyloid protein in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hirano bodies and related neuronal inclusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two actin binding proteins, actin depolymerizing factor and cofilin, are associated with Hirano bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress after acute and chronic application of beta-amyloid fragment 25-35 in cortical cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339026

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3711-05.2005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725891&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725891&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725891&resulttype=core&format=json

12 May 2020

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