Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis (Q46863515)

25 December 2017

title

Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis (English)

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13

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Owen J Sansom

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author name string

Charles E Patek

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Mark J Arends

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William A H Wallace

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Feijun Luo

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Feijun Luo

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Suzanne Hagan

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David G Brownstein

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Lorraine Rose

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Paul S Devenney

9

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Marion Walker

10

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Sarah J Plowman

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Rachel L Berry

12

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David J Harrison

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Martin L Hooper

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language of work or name

English

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publication date

17 November 2007

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25 December 2017

Experimental Cell Research

published in

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25 December 2017

volume

314

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issue

5

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page(s)

1105-1114

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25 December 2017

RAS oncogenes: the first 30 years.

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While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

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Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

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10.1016/J.YEXCR.2007.11.004

7 January 2021

Identifiers

DOI

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25 December 2017

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25 December 2017