In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. (Q46902979)

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6 February 2020

title

In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450 (English)

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6 February 2020

5

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4

Koichi Haraguchi

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6 February 2020

3

Yoshihisa Kato

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2

Chiho Ohta

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6 February 2020

1

Nobuyuki Koga

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6 February 2020

author name string

Kazunori Ogawa

series ordinal

6

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6 February 2020

Hideaki Ohta

series ordinal

7

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Masamichi Yano

series ordinal

8

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6 February 2020

language of work or name

English

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publication date

5 July 2011

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6 February 2020

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6 February 2020

volume

41

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issue

11

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6 February 2020

page(s)

927-933

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4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.

6 February 2020

cites work

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids

21 January 2018

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In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s

21 January 2018

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Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Cytochrome P450s and other enzymes in drug metabolism and toxicity

21 January 2018

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Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo

21 January 2018

1 reference

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Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3',4'-didemethylnobiletin, derived from nobiletin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Identification of nobiletin metabolites in mouse urine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Mechanism of neurotrophic action of nobiletin in PC12D cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

In vitro biotransformation of flavonoids by rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Flavonoid composition of fruit tissues of citrus species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Inhibition and induction of human cytochrome P450 (CYP) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

Urinary metabolites of nobiletin orally administered to rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.593208

10.3109/00498254.2011.593208

21 January 2018

Identifiers

DOI

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6 February 2020

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