Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study. (Q46923024)

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scientific article published in November 2007

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English	Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.	scientific article published in November 2007

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scholarly article

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9 January 2020

Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study (English)

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9 January 2020

1 reference

based on heuristic

inferred from title

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pharmacodynamics

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based on heuristic

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pharmacokinetics

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based on heuristic

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11

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Susan M Blaney

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26 December 2017

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Terzah M Horton

1

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9 January 2020

Patrick A Thompson

2

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9 January 2020

Stacey L Berg

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9 January 2020

Peter C Adamson

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9 January 2020

Ashish M Ingle

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9 January 2020

M Eileen Dolan

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9 January 2020

Shannon M Delaney

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9 January 2020

Madhuri Hedge

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9 January 2020

Heidi L Weiss

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9 January 2020

Meng-Fen Wu

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9 January 2020

Children's Oncology Group Study

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Susan M Blaney

11

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9 January 2020

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publication date

1 November 2007

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9 January 2020

Journal of Clinical Oncology

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9 January 2020

25

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9 January 2020

31

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9 January 2020

4922-4928

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Europe PubMed Central

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9 January 2020

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

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Loci for efficient detection of microsatellite instability in hereditary non-polyposis colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Evaluation of temozolomide in a SCID mouse model of human B-cell precursor leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Microsatellite instability in lymphoid leukemia and lymphoma cell lines but not in myeloid leukemia cell lines

1 reference

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12 December 2020

based on heuristic

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Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Temozolomide and treatment of malignant glioma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

1 reference

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12 December 2020

based on heuristic

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Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability and cytogenetic survey in myeloid leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy-related and secondary acute myeloid leukaemia and myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical relevance of MGMT in the treatment of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of temozolomide in relapsed/refractory acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mismatch repair deficiency in hematological malignancies with microsatellite instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability in hematological malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of sporadic colon cancer by patterns of genomic instability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-methylguanine-DNA methyltransferase activity and promoter methylation status in pediatric rhabdomyosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temozolomide in patients with advanced cancer: phase I and pharmacokinetic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MGMT: its role in cancer aetiology and cancer therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic silencing of the MGMT gene in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation of the putative tumor-suppressor genes DCC, p51/63 and O6-methylguanine-DNA methyltransferase (MGMT) and loss of their expressions in cell lines of hematological malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

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Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of temozolomide in human plasma and urine by high-performance liquid chromatography after solid-phase extraction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of expression of the human MSH3 gene in hematological malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of temozolomide in the treatment of central nervous system tumor xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability and other molecular abnormalities in childhood acute lymphoblastic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability during the progression of acute myelocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of O6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability in adult T-cell leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite analysis in childhood acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of temozolomide in paediatric patients with advanced cancer. United Kingdom Children's Cancer Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of 3-methyl-(triazen-1-yl)imidazole-4-carboximide following administration of temozolomide to patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication errors in hematological neoplasias: genomic instability in progression of disease is different among different types of leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971589

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1200/JCO.2007.12.0667

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971589%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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