The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. (Q46968736)

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8 January 2020

title

The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis (English)

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8 January 2020

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4

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Mark P Burns

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author name string

Hyang-Sook Hoe

1

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Matthew J Cooper

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Marcel van der Brug

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Geetanjali Chakraborty

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Casandra M Cartagena

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Daniel T S Pak

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G William Rebeck

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Mark R Cookson

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language of work or name

English

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publication date

1 October 2007

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8 January 2020

published in

Journal of Neuroscience

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volume

27

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issue

40

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page(s)

10895-10905

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describes a project that uses

8 January 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

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The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

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ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3

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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

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Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

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12 December 2020

10.1523/JNEUROSCI.3135-07.2007

Identifiers

DOI

1 reference

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8 January 2020

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8 January 2020

PubMed publication ID

17913923

1 reference