Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase (Q46985231)

27 December 2017

title

Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase (English)

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27 December 2017

2

Arieh Warshel

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27 December 2017

Hanbin Liu

1

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27 December 2017

language of work or name

English

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publication date

16 June 2007

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27 December 2017

Journal of Physical Chemistry B

published in

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27 December 2017

volume

111

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27 December 2017

issue

27

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27 December 2017

page(s)

7852-7861

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27 December 2017

Enzymology takes a quantum leap forward

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The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling

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How important are entropic contributions to enzyme catalysis?

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Enzyme dynamics and tunneling enhanced by compression in the hydrogen abstraction catalyzed by soybean lipoxygenase-1

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Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase

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Hybrid quantum/classical path integral approach for simulation of hydrogen transfer reactions in enzymes.

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Density-functional investigation on the mechanism of H-atom abstraction by lipoxygenase

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The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

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Dynamics of enzymatic reactions

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Proton-coupled electron transfer in soybean lipoxygenase

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Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems

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Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.

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Electrostatic basis for enzyme catalysis

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Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

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Large kinetic isotope effects in enzymatic proton transfer and the role of substrate oscillations

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Simulations of the large kinetic isotope effect and the temperature dependence of the hydrogen atom transfer in lipoxygenase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Quantum mechanical methods for enzyme kinetics

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Identifiers

DOI

10.1021/JP070938F

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27 December 2017

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27 December 2017