CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans (Q47068715)

4 January 2018

title

CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans (English)

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4 January 2018

main subject

Caenorhabditis elegans

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Cullin-2 CELE_ZK520.4

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GOA release 2020-03-11

author name string

Feng H

1

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4 January 2018

Zhong W

2

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4 January 2018

Punkosdy G

3

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4 January 2018

Gu S

4

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4 January 2018

Zhou L

5

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4 January 2018

Seabolt EK

6

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4 January 2018

Kipreos ET

7

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4 January 2018

publication date

1 December 1999

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4 January 2018

published in

Nature Cell Biology

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4 January 2018

volume

1

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4 January 2018

page(s)

486-492

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4 January 2018

issue

8

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4 January 2018

https://scigraph.springernature.com/pub.10.1038/70272

exact match

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cites work

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The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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1 reference

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

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1 reference

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Polyploid tissues in the nematode Caenorhabditis elegans.

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

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Mitotic chromosome condensation.

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

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A trans-spliced leader sequence on actin mRNA in C. elegans.

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Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

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7 January 2021

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

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7 January 2021

The VHL tumour-suppressor gene paradigm

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7 January 2021

DNA synthesis and the control of embryonic gene expression in C. elegans

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7 January 2021

Phosphorylation of histone H3 is required for proper chromosome condensation and segregation

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Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1

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Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle

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7 January 2021

Reverse genetics: from gene sequence to mutant worm.

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7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

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Identifiers

DOI

10.1038/70272

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4 January 2018

PubMed ID

10587644

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4 January 2018