Safety, efficacy and weight effect of two 11β-HSD1 inhibitors in metformin-treated patients with type 2 diabetes. (Q47173372)

11 January 2018

title

Safety, efficacy and weight effect of two 11β-HSD1 inhibitors in metformin-treated patients with type 2 diabetes. (English)

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Hans-Ulrich Häring

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object named as

H-U Häring

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author name string

T Heise

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L Morrow

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C Kapitza

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M Abt

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M Ramsauer

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M-C Magnone

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S Fuerst-Recktenwald

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publication date

9 June 2014

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Diabetes, Obesity and Metabolism

published in

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volume

16

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page(s)

1070-1077

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issue

11

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Management of diabetes across the course of disease: minimizing obesity-associated complications

cites work

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Redefining treatment success in type 2 diabetes mellitus: Comprehensive targeting of core defects

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Therapeutic targets to reduce cardiovascular disease in type 2 diabetes

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Endocrine function in human obesity

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Mechanisms involved in the side effects of glucocorticoids

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Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase

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Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

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A transgenic model of visceral obesity and the metabolic syndrome

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Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

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The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy

21 January 2018

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Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults

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Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome.

21 January 2018

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11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

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Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

21 January 2018

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

21 January 2018

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Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

21 January 2018

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Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibition

21 January 2018

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Clinical effectiveness and cost-effectiveness of pioglitazone and rosiglitazone in the treatment of type 2 diabetes: a systematic review and economic evaluation

21 January 2018

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11β-Hydroxysteroid dehydrogenase type 1 inhibition in type 2 diabetes mellitus

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/DOM.12317

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11 January 2018

PubMed ID

24828020

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11 January 2018