Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors (Q47196688)

11 January 2018

title

Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors (English)

1 reference

11 January 2018

traditional Chinese medicine

main subject

1 reference

object named as

traditional Chinese medicine

17 February 2024

1

1 reference

11 January 2018

Wolfgang Meyerhof

5

object named as

Wolfgang Meyerhof

1 reference

11 January 2018

author name string

Ming Gu

2

1 reference

11 January 2018

Shengjie Fan

3

1 reference

11 January 2018

Cheng Huang

4

1 reference

11 January 2018

publication date

21 August 2017

1 reference

11 January 2018

Chemical Biology and Drug Design

published in

1 reference

11 January 2018

A novel family of mammalian taste receptors

cites work

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

T2Rs function as bitter taste receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

A family of candidate taste receptors in human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Adaptive diversification of bitter taste receptor genes in Mammalian evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Functions of human bitter taste receptors depend on N-glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Structural requirements of bitter taste receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The cell biology of taste

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Is the bitter rejection response always adaptive?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Gustatory and extragustatory functions of mammalian taste receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Where is the hope for drug discovery? Let history tell the future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Pharmacokinetic behavior of gentiopicroside from decoction of Radix Gentianae, Gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The human taste receptor hTAS2R14 responds to a variety of different bitter compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Bitter and sweet taste receptors in the respiratory epithelium in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Taste perception: from the tongue to the testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

TAS2R bitter taste receptors regulate thyroid function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Impact of bitter taste on gastric motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Chloroquine stimulates Cl- secretion by Ca2+ activated Cl- channels in rat ileum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Chemesthesis and the chemical senses as components of a "chemofensor complex".

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Stimulation of insulin secretion by denatonium, one of the most bitter-tasting substances known

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

BitterDB: a database of bitter compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Bitter taste receptors influence glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.13089

21 January 2018

Identifiers

DOI

10.1111/CBDD.13089

1 reference

11 January 2018

PubMed ID

28834122

1 reference

11 January 2018