α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway. (Q47202550)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Tracey C. Dickson

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Ruth E J Musgrove

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

publication date

31 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

published in

Neurotoxicity Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

358-369

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12640-012-9352-5

12 February 2020

exact match

0 references

cites work

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Molecular targets of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

The genetics of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Chemical-induced apoptosis: formation of the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

alpha-Synuclein affects the MAPK pathway and accelerates cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Controlling the mass action of alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Isolation of mitochondria from the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Apoptosis, excitotoxicity, and neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Neuroprotective upregulation of endogenous α-synuclein precedes ubiquitination in cultured dopaminergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Mitochondrial dysfunction and oxidative stress in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Mitochondrial association of alpha-synuclein causes oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Complex I deficiency in Parkinson's disease frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

c-fos mRNA expression in rat cortical neurons during glutamate-mediated excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

alpha-Synuclein at the synaptic gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Detection and measurement of reactive oxygen intermediates in mitochondria and cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Overexpression of alpha-synuclein down-regulates BDNF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

Induction of neuronal death by α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-012-9352-5

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

21 January 2018

1 reference

12 December 2020

The synucleins are a family of redox-active copper binding proteins

1 reference

12 December 2020

Immunocytochemical techniques for studying apoptosis in primary sympathetic neurons

1 reference

12 December 2020

Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

1 reference

12 December 2020

α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

1 reference

12 December 2020

1 reference

12 December 2020

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms

1 reference

12 December 2020

Mechanism of toxicity in rotenone models of Parkinson's disease

1 reference

12 December 2020

10.1007/S12640-012-9352-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936601%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference