Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability (Q47264611)

12 January 2018

title

Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability (English)

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12 January 2018

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1

Christine Richardson

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12 January 2018

author name string

Jeremy M Stark

series ordinal

2

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12 January 2018

Melissa Ommundsen

series ordinal

3

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12 January 2018

Maria Jasin

series ordinal

4

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12 January 2018

language of work or name

English

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publication date

1 January 2004

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12 January 2018

published in

Oncogene

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12 January 2018

volume

23

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12 January 2018

page(s)

546-553

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12 January 2018

issue

2

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12 January 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207098

exact match

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cites work

The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells

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Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

21 January 2018

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Effects of HsRad51 overexpression on cell proliferation, cell cycle progression, and apoptosis

21 January 2018

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The Myc/Max/Mad network and the transcriptional control of cell behavior

21 January 2018

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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

21 January 2018

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Homology-directed repair is a major double-strand break repair pathway in mammalian cells

21 January 2018

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Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication

21 January 2018

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The BRCA2 gene product functionally interacts with p53 and RAD51

21 January 2018

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ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair

21 January 2018

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

21 January 2018

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DNA helicases, genomic instability, and human genetic disease

21 January 2018

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Chromosomal stability and the DNA double-stranded break connection

21 January 2018

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Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

21 January 2018

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ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

21 January 2018

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7 January 2021

Differential timing and control of noncrossover and crossover recombination during meiosis

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7 January 2021

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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7 January 2021

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

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7 January 2021

One-sided invasion events in homologous recombination at double-strand breaks

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7 January 2021

Translocations involving c-myc and c-myc function

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7 January 2021

Interaction of p53 with the human Rad51 protein

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7 January 2021

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

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7 January 2021

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

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7 January 2021

Gene conversion in mitotically dividing cells: a view from Drosophila

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7 January 2021

Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage

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7 January 2021

Centrosomes split in the presence of impaired DNA integrity during mitosis

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7 January 2021

Homologous integration in mammalian cells without target gene selection

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7 January 2021

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

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7 January 2021

Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms.

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7 January 2021

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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7 January 2021

p53 and ATM: cell cycle, cell death, and cancer.

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7 January 2021

The essential functions of human Rad51 are independent of ATP hydrolysis

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7 January 2021

Molecular genetics of yeast mating type

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Frequent chromosomal translocations induced by DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

The double-strand-break repair model for recombination

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

A double-strand break in a chromosomal LINE element can be repaired by gene conversion with various endogenous LINE elements in mouse cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Cancer susceptibility and the functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Gene targeting is enhanced in human cells overexpressing hRAD51.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207098

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207098

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12 January 2018

PubMed ID

14724582

1 reference

12 January 2018