The Hsp90 complex--a super-chaperone machine as a novel drug target (Q47280893)

13 January 2018

review article

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title

The Hsp90 complex--a super-chaperone machine as a novel drug target (English)

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13 January 2018

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Scheibel T

1

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13 January 2018

Buchner J

series ordinal

2

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13 January 2018

language of work or name

English

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publication date

1 September 1998

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13 January 2018

published in

Biochemical Pharmacology

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13 January 2018

volume

56

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13 January 2018

page(s)

675-682

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13 January 2018

issue

6

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13 January 2018

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures

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HSP 90 alpha and HSP 90 beta genes are present in the zebrafish and are differentially regulated in developing embryos.

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The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila

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Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.

7 January 2021

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Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

7 January 2021

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Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulum

7 January 2021

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Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase

7 January 2021

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Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids

7 January 2021

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

7 January 2021

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Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

7 January 2021

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Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

7 January 2021

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Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity

7 January 2021

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Interaction of Endoplasmic Reticulum Chaperone GRP94 with Peptide Substrates Is Adenine Nucleotide-independent

7 January 2021

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A mouse tumor-specific transplantation antigen is a heat shock-related protein

7 January 2021

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Heat shock proteins transfer peptides during antigen processing and CTL priming

7 January 2021

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Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast

7 January 2021

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A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

7 January 2021

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

7 January 2021

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Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

7 January 2021

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Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

7 January 2021

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An atypical topoisomerase II from Archaea with implications for meiotic recombination

7 January 2021

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Hsp90 chaperones protein folding in vitro.

7 January 2021

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Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo

7 January 2021

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The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding

7 January 2021

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Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones

7 January 2021

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Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

7 January 2021

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ATP-binding properties of human Hsp90.

7 January 2021

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Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

7 January 2021

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Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

7 January 2021

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Isolation of Hsp90 mutants by screening for decreased steroid receptor function

7 January 2021

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Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes.

7 January 2021

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In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

7 January 2021

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Stable transformation of an Arabidopsis cell suspension culture with firefly luciferase providing a cellular system for analysis of chaperone activity in vivo

7 January 2021

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Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle

7 January 2021

1 reference

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The dissociation of ATP from hsp70 of Saccharomyces cerevisiae is stimulated by both Ydj1p and peptide substrates

7 January 2021

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Chaperone function of Hsp90-associated proteins

7 January 2021

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Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23

7 January 2021

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Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor

7 January 2021

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Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70

7 January 2021

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A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains

7 January 2021

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The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor

7 January 2021

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Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways

7 January 2021

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The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast

7 January 2021

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In vivo analysis of the Hsp90 cochaperone Sti1 (p60)

7 January 2021

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A cyclophilin function in Hsp90-dependent signal transduction

7 January 2021

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Geldanamycin, a new antibiotic

7 January 2021

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Effects of herbimycin derivatives on src oncogene function in relation to antitumor activity

7 January 2021

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900120-8

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900120-8

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900120-8

Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900120-8

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900120-8

Growth inhibition of virus transformed cells in vitro and antitumor activity in vivo of geldanamycin and its derivatives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2898%2900120-8

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(98)00120-8

1 reference

13 January 2018

PubMed ID

9751071

1 reference

13 January 2018