Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome (Q47412555)

15 January 2018

title

Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome (English)

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15 January 2018

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Luis A Martinez

1

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15 January 2018

Maria Victoria Tejada-Simon

series ordinal

2

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15 January 2018

publication date

11 November 2017

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15 January 2018

published in

Molecular Neurobiology

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15 January 2018

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

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The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

21 January 2018

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The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses

21 January 2018

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Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.

21 January 2018

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Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome

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Fmr1 KO mice as a possible model of autistic features.

21 January 2018

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Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome

21 January 2018

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NNZ-2566, a novel analog of (1-3) IGF-1, as a potential therapeutic agent for fragile X syndrome.

21 January 2018

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Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome

21 January 2018

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Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome

21 January 2018

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Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein

21 January 2018

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Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Advances in the treatment of fragile X syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond

21 January 2018

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The challenges of clinical trials in fragile X syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Control of dendritic development by theDrosophila fragile X-relatedgene involves the small GTPase Rac1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes

21 January 2018

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Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP

21 January 2018

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Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency

21 January 2018

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Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Labelling and optical erasure of synaptic memory traces in the motor cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Forgetting is regulated through Rac activity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Rho GTPases, dendritic structure, and mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Rho GTPase signaling at the synapse: implications for intellectual disability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase,

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Exploring the multifactorial nature of autism through computational systems biology: calcium and the Rho GTPase RAC1 under the spotlight

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Trace but not delay fear conditioning requires attention and the anterior cingulate cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

A role for prefrontal cortex in memory storage for trace fear conditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Maladaptive dendritic spine remodeling contributes to diabetic neuropathic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Trace conditioning and the hippocampus: the importance of contiguity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Distribution of fragile X mental retardation protein in the human auditory brainstem

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Deletion of Fmr1 alters function and synaptic inputs in the auditory brainstem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Failed stabilization for long-term potentiation in the auditory cortex of FMR1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Role of N-methyl-D-aspartate receptors in the induction of synaptic potentiation by burst stimulation patterned after the hippocampal theta-rhythm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Loss of hippocampal theta rhythm results in spatial memory deficit in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Hippocampal formation theta activity and movement selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-017-0819-5

Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory

21 January 2018

1 reference

12 December 2020

Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments

1 reference

12 December 2020

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.

1 reference

12 December 2020

Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho

1 reference

12 December 2020

10.1007/S12035-017-0819-5

Identifiers

DOI

1 reference

15 January 2018

1 reference

15 January 2018