Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. (Q47610304)

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28 December 2019

title

Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat (English)

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28 December 2019

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4

James A Richardson

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28 December 2019

author name string

Carsten T Beuckmann

1

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28 December 2019

Christopher M Sinton

2

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S Clay Williams

3

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28 December 2019

Robert E Hammer

5

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Takeshi Sakurai

6

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Masashi Yanagisawa

7

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language of work or name

English

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publication date

1 May 2004

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28 December 2019

published in

Journal of Neuroscience

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volume

24

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28 December 2019

page(s)

4469-4477

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28 December 2019

issue

18

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Distribution of orexin neurons in the adult rat brain

28 December 2019

cites work

1 reference

12 December 2020

Narcolepsy and other causes of excessive daytime sleepiness

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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

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Reduced number of hypocretin neurons in human narcolepsy

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12 December 2020

Aprepro-orexingene polymorphism is associated with narcolepsy: Table 1

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Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

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12 December 2020

Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines

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Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation.

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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

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Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives

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Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.

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Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy.

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Orexin (hypocretin) neurons contain dynorphin.

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A commentary on the neurobiology of the hypocretin/orexin system

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Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.

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The sleep switch: hypothalamic control of sleep and wakefulness

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CSF hypocretin/orexin levels in narcolepsy and other neurological conditions.

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The hypocretins: setting the arousal threshold

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12 December 2020

Analysis of onset location, laterality and propagation of cataplexy in canine narcolepsy.

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The role of hypocretins (orexins) in sleep regulation and narcolepsy.

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Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation

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Release of hypocretin (orexin) during waking and sleep states.

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12 December 2020

The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias

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12 December 2020

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

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12 December 2020

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

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12 December 2020

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

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Narcolepsy. Clinical features and aetiology.

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Adenosine analogs and sleep in rats

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12 December 2020

An Etiology of Narcolepsy-Cataplexy and a Proposed Cataplexy Neuromechanism

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Circadian rhythms in narcolepsy: studies on a 90 minute day.

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Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans

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Pharmacological aspects of human and canine narcolepsy

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

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Narcolepsy in seven dogs

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12 December 2020

Genetic and familial aspects of narcolepsy

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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Development of cataplexy in genetically narcoleptic Dobermans

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

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12 December 2020

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area.

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12 December 2020

10.1523/JNEUROSCI.5560-03.2004

Identifiers

DOI

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