The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner. (Q47659569)

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English	The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.	scientific article

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scholarly article

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Europe PubMed Central

4 February 2018

http://europepmc.org/abstract/MED/12944913

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner. (English)

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Europe PubMed Central

4 February 2018

http://europepmc.org/abstract/MED/12944913

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acute myeloid leukemia

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based on heuristic

inferred from title

11

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http://europepmc.org/abstract/MED/12944913

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Claudia Schoch

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Europe PubMed Central

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Susanne Schnittger

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Susanne Schnittger

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Marius Ueffing

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4 February 2018

http://europepmc.org/abstract/MED/12944913

author name string

Annika Elsässer

1

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4 February 2018

http://europepmc.org/abstract/MED/12944913

Michael Franzen

2

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http://europepmc.org/abstract/MED/12944913

Alexander Kohlmann

3

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Europe PubMed Central

4 February 2018

http://europepmc.org/abstract/MED/12944913

Martin Weisser

4

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4 February 2018

http://europepmc.org/abstract/MED/12944913

Venkateshwar A Reddy

7

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4 February 2018

http://europepmc.org/abstract/MED/12944913

Sebastian Burel

8

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4 February 2018

http://europepmc.org/abstract/MED/12944913

Dong-Er Zhang

9

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4 February 2018

http://europepmc.org/abstract/MED/12944913

Wolfgang Hiddemann

12

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http://europepmc.org/abstract/MED/12944913

Gerhard Behre

13

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1 August 2003

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http://europepmc.org/abstract/MED/12944913

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http://europepmc.org/abstract/MED/12944913

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http://europepmc.org/abstract/MED/12944913

5646-5657

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4 February 2018

http://europepmc.org/abstract/MED/12944913

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206673

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Common themes in the pathogenesis of acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206673

21 January 2018

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1 reference

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21 January 2018

Modulation of MEK activity during G-CSF signaling alters proliferative versus differentiative balancing

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21 January 2018

Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.

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21 January 2018

c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.

1 reference

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21 January 2018

Analysis of the modulation of transcriptional activity in myelopoiesis and leukemogenesis

1 reference

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11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop

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Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

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Proliferative activity of leukaemic blasts and cytosine arabinoside pharmacodynamics are associated with cytogenetically defined prognostic subgroups in acute myeloid leukaemia

1 reference

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21 January 2018

rhG-CSF affects genes involved in mitogen signalling and early gene expression in the ovarian cancer cell line HEY.

1 reference

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21 January 2018

Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206673

21 January 2018

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

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21 January 2018

A cytoplasmic inhibitor of the JNK signal transduction pathway

1 reference

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21 January 2018

The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206673

21 January 2018

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206673

21 January 2018

The regulation of AP-1 activity by mitogen-activated protein kinases

1 reference

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21 January 2018

Granulocyte colony-stimulating factor and its receptor in acute promyelocytic leukemia.

1 reference

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21 January 2018

Inhibition of growth of human malignant glioblastoma in nude mice by antagonists of bombesin/gastrin-releasing peptide

1 reference

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Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.

1 reference

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21 January 2018

Oncogenic transcription factors in the human acute leukemias

1 reference

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Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins

1 reference

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21 January 2018

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

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21 January 2018

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206673

21 January 2018

Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.

1 reference

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21 January 2018

Phosphorylation of c-jun mediated by MAP kinases.

1 reference

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21 January 2018

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

1 reference

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21 January 2018

Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment

1 reference

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21 January 2018

Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway

1 reference

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21 January 2018

Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation

1 reference

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21 January 2018

Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

1 reference

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21 January 2018

Activation of the JNK pathway is essential for transformation by the Met oncogene

1 reference

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21 January 2018

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

1 reference

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21 January 2018

Control of cell cycle progression by c-Jun is p53 dependent

1 reference

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21 January 2018

Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene

1 reference

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21 January 2018

c-jun expression and growth stimulation in human ovarian carcinoma cell lines following exposure to cytokines

1 reference

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21 January 2018

Tumourigenicity of MTG8, a leukaemia-related gene, in concert with v-Ha-ras gene in BALB/3T3 cells

1 reference

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21 January 2018

Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

1 reference

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21 January 2018

Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter

1 reference

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Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

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21 January 2018

The JIP group of mitogen-activated protein kinase scaffold proteins

1 reference

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

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Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR

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Use of a promoterless Renilla luciferase vector as an internal control plasmid for transient co-transfection assays of Ras-mediated transcription activation

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Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response

1 reference

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Identifiers

10.1038/SJ.ONC.1206673

1 reference

Europe PubMed Central

4 February 2018

http://europepmc.org/abstract/MED/12944913

1 reference

Europe PubMed Central

4 February 2018

http://europepmc.org/abstract/MED/12944913

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