Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans (Q47682285)

4 February 2018

title

Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans (English)

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main subject

lymphocyte

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author

Catherine M. Hawrylowicz

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author name string

Rückemann K

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Fairbanks LD

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Carrey EA

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Richards DF

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Kirschbaum B

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Simmonds HA

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language of work or name

English

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publication date

1 August 1998

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Journal of Biological Chemistry

published in

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volume

273

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issue

34

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page(s)

21682-21691

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Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

cites work

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In vitro and in vivo effects of leflunomide, brequinar, and cyclosporine on pyrimidine biosynthesis

21 January 2018

1 reference

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Leflunomide interferes with pyrimidine nucleotide biosynthesis

21 January 2018

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The development of Brequinar as an immunosuppressive drug for transplantation

21 January 2018

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In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine

21 January 2018

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Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine

21 January 2018

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Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

21 January 2018

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Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders

21 January 2018

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Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation

21 January 2018

1 reference

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Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

21 January 2018

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Leflunomide, a reversible inhibitor of pyrimidine biosynthesis?

21 January 2018

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Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program.

21 January 2018

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Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide

21 January 2018

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Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

21 January 2018

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Enzymes of nucleotide biosynthesis: differences between intact and lysed cells as well as between species and tissues can be important

21 January 2018

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Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

21 January 2018

1 reference

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Proteolytic cleavage of the multienzyme polypeptide CAD to release the mammalian aspartate transcarbamoylase. Biochemical comparison with the homologous Escherichia coli catalytic subunit

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.34.21682

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4 February 2018

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4 February 2018