Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. (Q47720179)

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English	Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.	scientific article

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5 February 2018

http://europepmc.org/abstract/MED/22623658

Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. (English)

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PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/22623658

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15 May 2020

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Donna M Barten

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Patrizia Fanara

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Cathy Andorfer

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Nina Hoque

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Kristofor H Husted

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Gregory W Cadelina

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Lynn B Decarr

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Ling Yang

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Victoria Liu

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Chancy Fessler

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Joan Protassio

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Timothy Riff

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Holly Turner

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Christopher G Janus

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Sethu Sankaranarayanan

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Craig Polson

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Jere E Meredith

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Gemma Gray

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Amanda Hanna

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15 May 2020

Richard E Olson

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Soong-Hoon Kim

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Gregory D Vite

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Francis Y Lee

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Charles F Albright

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15 May 2020

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publication date

1 May 2012

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5 February 2018

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Journal of Neuroscience

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32

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7137-7145

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15 May 2020

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid peptide toxicity and microtubule-stabilizing drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epothilone D (Kosan/Roche).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MAP2/Tau family of microtubule-associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal integrity as a drug target

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protects microtubules in the axon from severing by katanin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule stabilizer ameliorates synaptic function and behavior in a mouse model for schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stabilization of hyperdynamic microtubules is neuroprotective in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-precision laser spectroscopy D/H and 18O/16O measurements of microliter natural water samples.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of microtubule dynamic instability in vitro by differentially phosphorylated stathmin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule binding and trapping at the tip of neurites regulate tau motion in living neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Addressing Alzheimer's disease tangles: from NAP to AL-108.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The microtubule cytoskeleton acts as a key downstream effector of neurotransmitter signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule tip-interacting proteins: a view from both ends

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau reduction prevents Abeta-induced defects in axonal transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic spine plasticity: new regulatory roles of dynamic microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxol facilitates axon regeneration in the mature CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The many faces of tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brief update on different roles of tau in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of microtubule cold stability by calmodulin-dependent and -independent phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substoichiometric binding of taxol suppresses microtubule dynamics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional studies of Alzheimer's disease tau protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22623658

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0188-12.2012

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622320&resulttype=core&format=json

15 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622320&resulttype=core&format=json

15 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622320&resulttype=core&format=json

15 May 2020

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