Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis. (Q47796440)

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English	Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis.	scientific article

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scholarly article

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis. (English)

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

author name string

Bernard Pirard

1

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Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

publication date

1 November 2003

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Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

Journal of Computer - Aided Molecular Design

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Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

17

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Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

11

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

785-796

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

https://scigraph.springernature.com/pub.10.1023/b:jcam.0000017498.74580.3d

0 references

The PPARs: from orphan receptors to drug discovery

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https://pubmed.ncbi.nlm.nih.gov/15072437

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A Novel Strategy for Improving Ligand Selectivity in Receptor-Based Drug Design

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

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Chemometric rationalization of the structural and physicochemical basis for selective cyclooxygenase-2 inhibition: toward more specific ligands.

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Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

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Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA.

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Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype

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Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes

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(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity

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Use of Relibase for retrieving complex three-dimensional interaction patterns including crystallographic packing effects

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Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family

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Identifiers

10.1023/B:JCAM.0000017498.74580.3D

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

DBLP publication ID

journals/jcamd/Pirard03

1 reference

DBLP Dataset 2021-01-02

28 January 2021

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

5 February 2018

http://europepmc.org/abstract/MED/15072437

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