Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production (Q47880180)

6 February 2018

title

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production (English)

1 reference

6 February 2018

0 references

8

1 reference

6 February 2018

Dirk Beher

object named as

Dirk Beher

10

0 references

Patrick C Fraering

object named as

Patrick C Fraering

11

0 references

author name string

Mitko Dimitrov

1

1 reference

6 February 2018

Jean-René Alattia

2

1 reference

6 February 2018

Thomas Lemmin

3

1 reference

6 February 2018

Rajwinder Lehal

4

1 reference

6 February 2018

Andrzej Fligier

5

1 reference

6 February 2018

Jemila Houacine

6

1 reference

6 February 2018

Ishrut Hussain

7

1 reference

6 February 2018

Matteo Dal Peraro

9

1 reference

6 February 2018

language of work or name

English

0 references

publication date

1 January 2013

1 reference

6 February 2018

published in

Nature Communications

1 reference

6 February 2018

volume

4

1 reference

6 February 2018

page(s)

2246

1 reference

6 February 2018

Amyloid plaque core protein in Alzheimer disease and Down syndrome

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Predisposing locus for Alzheimer's disease on chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Substrate-targeting gamma-secretase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Alzheimer's disease: clinical trials and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Bendix: intuitive helix geometry analysis and abstraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Exploring the chemical space of gamma-secretase modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Effects of membrane lipids on the activity and processivity of purified γ-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

VMD: visual molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Scalable molecular dynamics with NAMD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

SwissDock, a protein-small molecule docking web service based on EADock DSS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Fast docking using the CHARMM force field with EADock DSS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

BSP-SLIM: a blind low-resolution ligand-protein docking approach using predicted protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

7 January 2021

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

7 January 2021

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

7 January 2021

In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3246

7 January 2021

Identifiers

DOI

10.1038/NCOMMS3246

1 reference

6 February 2018

Dimensions Publication ID

ADS bibcode

2013NatCo...4.2246D

0 references

1000823660

0 references

1 reference

6 February 2018