Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study (Q47930930)

6 February 2018

title

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study (English)

1 reference

6 February 2018

1 reference

0 references

5

Christian Haass

0 references

author name string

Brigitte Nuscher

1

1 reference

6 February 2018

Frits Kamp

2

1 reference

6 February 2018

Thomas Mehnert

3

1 reference

6 February 2018

Sabine Odoy

4

1 reference

6 February 2018

Philipp J Kahle

6

1 reference

6 February 2018

Klaus Beyer

7

1 reference

6 February 2018

language of work or name

English

0 references

publication date

17 March 2004

1 reference

6 February 2018

Journal of Biological Chemistry

number of pages

10

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

6 February 2018

volume

279

1 reference

6 February 2018

issue

21

1 reference

6 February 2018

page(s)

21966-21975

1 reference

6 February 2018

Alpha-synuclein and neurodegenerative diseases

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

A broken alpha -helix in folded alpha -Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Membrane binding and self-association of alpha-synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Lipid binding inhibits alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Titration calorimetry of lipid-peptide interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Direct measurement of protein binding energetics by isothermal titration calorimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Interaction of a mitochondrial presequence with lipid membranes: role of helix formation for membrane binding and perturbation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Thermodynamics of the coil-alpha-helix transition of amphipathic peptides in a membrane environment: the role of vesicle curvature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

α-Synuclein Association with Phosphatidylglycerol Probed by Lipid Spin Labels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Asymmetry of lipid organization in cholinergic synaptic vesicle membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Sphingomyelin: biophysical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

A calorimetric and fluorescent probe study of the gel-liquid crystalline phase transition in small, single-lamellar dipalmitoylphosphatidylcholine vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Phase transitions in phospholipid model membranes of different curvature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

The enthalpy of the alanine peptide helix measured by isothermal titration calorimetry using metal-binding to induce helix formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

The mechanism of alpha-helix formation by peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Critical effects from lipid-protein interaction in membranes. I. Theoretical description

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Interaction of the sperm adhesive protein, bindin, with phospholipid vesicles. I. Specific association of bindin with gel-phase phospholipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Analysis of the membrane-interacting domain of the sea urchin sperm adhesive protein bindin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Interaction between the 35 kDa apolipoprotein of pulmonary surfactant and saturated phosphatidylcholines. Effects of temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

Distribution of lipids in subcellular particles of guinea-pig brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

The preparation and characterization of synaptic vesicles of high purity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401076200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401076200

1 reference

6 February 2018

1 reference

6 February 2018