TET2 is essential for survival and hematopoietic stem cell homeostasis (Q47951540)

7 February 2018

title

TET2 is essential for survival and hematopoietic stem cell homeostasis (English)

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7 February 2018

main subject

stem cell homeostasis

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K Shide

1

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T Kameda

2

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H Shimoda

3

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T Yamaji

4

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H Abe

5

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A Kamiunten

6

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M Sekine

7

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T Hidaka

8

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K Katayose

9

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Y Kubuki

10

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S Yamamoto

11

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T Miike

12

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H Iwakiri

13

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S Hasuike

14

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K Nagata

15

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K Marutsuka

16

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A Iwama

17

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T Matsuda

18

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A Kitanaka

19

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K Shimoda

20

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publication date

3 April 2012

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published in

Leukemia

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volume

26

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issue

10

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page(s)

2216-2223

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https://scigraph.springernature.com/pub.10.1038/leu.2012.94

exact match

0 references

cites work

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

A gain-of-function mutation of JAK2 in myeloproliferative disorders

21 January 2018

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

21 January 2018

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation.

21 January 2018

1 reference

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Mutation in TET2 in myeloid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.94

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Characterization of Ayu17-449 gene expression and resultant kidney pathology in a knockout mouse model

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.94

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

inferred from DOI database lookup

7 January 2021

based on heuristic

Gene expression profiling: identification of genes with altered expression in Ayu17-449 knockout mice.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

inferred from DOI database lookup

7 January 2021

based on heuristic

The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.94

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2012.94

1 reference

7 February 2018

PubMed ID

22469782

1 reference

7 February 2018