Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. (Q48158635)

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English	Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.	scientific article

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scholarly article

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. (English)

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

author name string

W Löscher

1

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

D Hörstermann

2

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

publication date

1 March 1994

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

349

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

3

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

270-278

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Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

https://scigraph.springernature.com/pub.10.1007/bf00169293

0 references

Acute effects of sodium valproate and gamma-vinyl GABA on regional amino acid metabolism in the rat brain: incorporation of 2-[14C]glucose into amino acids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Micro-vacuolation in rat brains after long term administration of GABA-transaminase inhibitors. Comparison of effects of ethanolamine-O-sulphate and vigabatrin

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Differential effects of n-dipropylacetate and amino-oxyacetic acid on Gm-aminobutyric acid levels in discrete areas of rat brain

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Metabolic inhibitors and subcellular distribution of GABA

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Sodium valproate stimulates the particulate form of glutamine synthetase in rat brain.

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Effects of Vigabatrin (γ-vinyl GAB A) on Neuro transmission-Related Amino Acids and on GAB A nd Benzodiazepine Receptor Binding in Rats

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of GABA-transaminase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Anticonvulsant properties of amino-oxyacetic acid.

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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inferred from PubMed ID database lookup

Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aspartate aminotransferase for synthesis of transmitter glutamate in the medulla oblongata: effect of aminooxyacetic acid and 2-oxoglutarate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dipropylacetate on the glycine cleavage enzyme system and glycine levels. A possible experimental approach to non-ketotic hyperglycinemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Vinyl GABA: effects of chronic administration on the metabolism of GABA and other amino compounds in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Aminooxyacetic acid produces excitotoxic lesions in the rat striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study of the pharmacology of inhibitors of GABA-metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between drug-induced increases of GABA levels in discrete brain areas and different pharmacological effects in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of transmitter gamma-aminobutyric acid (GABA) synthesis and metabolism illustrated by the effect of gamma-vinyl GABA and hypoglycemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: Evidence for mediation by NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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?-Vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of GABA metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of vigabatrin (gamma-vinyl-gamma-aminobutyric acid) affects the levels of both inhibitory and excitatory amino acids in rat cerebrospinal fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Valproate increases cerebrospinal fluid glutamine levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: a reevaluation of aminooxyacetic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Aminooxyacetic acid causes selective neuronal loss in layer III of the rat medial entorhinal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

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Amino Acid Neurotransmitters and New Approaches to Anticonvulsant Drug Action

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of inhibitors of GABA-transaminase for the determination of GABA turnover in mouse brain regions: an evaluation of aminooxyacetic acid and gabaculine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological actions of taurine

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https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

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Studies on the GABA pathway. II. The lack of effect of pyridoxal phosphate on GABA-KGA transaminase inhibition induced by amino-oxyacetic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABAergic mechanisms in the pathogenesis and treatment of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic aspects of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between alterations in brain GABA metabolism and seizure excitability following administration of GABA aminotransferase inhibitors and valproic acid-a re-evaluation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminooxyacetic acid: Correlation between biochemical effects, anticonvulsant action and toxicity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional alterations in brain amino acids after administration of the receptor antagonists MK-801 and CGP 39551 in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The action of gamma-vinyl-GABA and gamma-acetylenic-GABA on the resting and stimulated release of GABA in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of vigabatrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a synaptosomal model to determine drug-induced in vivo changes in GABA-levels of nerve endings in 11 brain regions of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory and excitatory amino acids in CSF of patients suffering from complex partial seizures during chronic treatment with gamma-vinyl GABA (vigabatrin)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8208305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00169293

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/8208305

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