Off-target mutations are rare in Cas9-modified mice. (Q48181926)

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15 February 2020

title

Off-target mutations are rare in Cas9-modified mice (English)

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15 February 2020

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4

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author name string

Vivek Iyer

1

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15 February 2020

Bin Shen

2

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15 February 2020

Wensheng Zhang

3

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15 February 2020

Thomas Keane

5

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15 February 2020

Xingxu Huang

6

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William C Skarnes

7

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publication date

1 June 2015

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15 February 2020

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volume

12

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issue

6

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15 February 2020

page(s)

479

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https://scigraph.springernature.com/pub.10.1038/nmeth.3408

15 February 2020

exact match

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cites work

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3408

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3408

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3408

Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3408

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3408

Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.3408

21 January 2018

Identifiers

DOI

10.1038/NMETH.3408

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15 February 2020

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