Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response. (Q48183000)

9 February 2018

title

Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response. (English)

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9 February 2018

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5

George K Dresser

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9 February 2018

author name string

Inna Y Gong

1

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Natalie Crown

2

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Colin M Suen

3

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Ute I Schwarz

4

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Michael J Knauer

6

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Daisuke Sugiyama

7

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Marianne K DeGorter

8

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Sarah Woolsey

9

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Rommel G Tirona

10

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Richard B Kim

11

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publication date

27 February 2012

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9 February 2018

published in

European Heart Journal

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volume

33

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issue

22

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page(s)

2856-2464a

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Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study

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Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis.

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Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.

21 January 2018

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Structure and stereochemistry of the active metabolite of clopidogrel

21 January 2018

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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

21 January 2018

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Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel

21 January 2018

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Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel

21 January 2018

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An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma.

21 January 2018

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Cytochrome p-450 polymorphisms and response to clopidogrel

21 January 2018

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Genetic determinants of response to clopidogrel and cardiovascular events

21 January 2018

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Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis

21 January 2018

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Effects of CYP2C19 genotype on outcomes of clopidogrel treatment

21 January 2018

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Dose comparisons of clopidogrel and aspirin in acute coronary syndromes

21 January 2018

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Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism

21 January 2018

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Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease

21 January 2018

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Effect of Paraoxonase-1 Polymorphism on Clinical Outcomes in Patients Treated With Clopidogrel After an Acute Myocardial Infarction

21 January 2018

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Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

21 January 2018

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Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel

21 January 2018

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Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients.

21 January 2018

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In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration

21 January 2018

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Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease

21 January 2018

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Differential sensitivity and kinetics of response of different ex vivo tests monitoring functional variability of platelet response to clopidogrel.

21 January 2018

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VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation

21 January 2018

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Impact of platelet reactivity on clinical outcomes after percutaneous coronary intervention. A collaborative meta-analysis of individual participant data

21 January 2018

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Paraoxonase-1 and clopidogrel efficacy

21 January 2018

1 reference

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Genetic Polymorphisms and the Impact of a Higher Clopidogrel Dose Regimen on Active Metabolite Exposure and Antiplatelet Response in Healthy Subjects

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1093/EURHEARTJ/EHS042

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9 February 2018

PubMed ID

22374717

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9 February 2018