Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine (Q48193936)

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scientific article published on 18 May 2010

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English	Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine	scientific article published on 18 May 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine (English)

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

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9 February 2018

http://europepmc.org/abstract/MED/20480276

Michael Sørensen

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http://europepmc.org/abstract/MED/20480276

Helle S. Waagepetersen

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Hendrik Vilstrup

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Hendrik Vilstrup

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9 February 2018

http://europepmc.org/abstract/MED/20480276

Susanne Keiding

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Susanne Keiding

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http://europepmc.org/abstract/MED/20480276

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Arne Schousboe

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http://europepmc.org/abstract/MED/20480276

Ursula Sonnewald

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Ursula Sonnewald

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http://europepmc.org/abstract/MED/20480276

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Renata Leke

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9 February 2018

http://europepmc.org/abstract/MED/20480276

Luis Eugenio Portela Fernandes de Souza

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Luis V Portela

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9 February 2018

http://europepmc.org/abstract/MED/20480276

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Torun M Melø

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9 February 2018

http://europepmc.org/abstract/MED/20480276

author name string

Malene Anker

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9 February 2018

http://europepmc.org/abstract/MED/20480276

Peter Ott

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http://europepmc.org/abstract/MED/20480276

publication date

18 May 2010

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Neurotoxicity Research

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9 February 2018

http://europepmc.org/abstract/MED/20480276

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Europe PubMed Central

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9 February 2018

http://europepmc.org/abstract/MED/20480276

3

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9 February 2018

http://europepmc.org/abstract/MED/20480276

496-510

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint

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The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy

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Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome.

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Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures.

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Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

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Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia.

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The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma

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Hepatic Encephalopathy.

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Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation

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21 January 2018

Pathophysiology of hepatic encephalopathy: a new look at ammonia

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Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex

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Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

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Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

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Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity

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21 January 2018

Cerebral ammonia metabolism in hyperammonemic rats

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21 January 2018

Hepatic encephalopathy: An update of pathophysiologic mechanisms

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Energy metabolism in brain cells: effects of elevated ammonia concentrations

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Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts

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Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy

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Glutamine-induced free radical production in cultured astrocytes

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Glutamine in the mechanism of ammonia-induced astrocyte swelling

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Potential mechanisms of enhanced GABA-mediated inhibitory neurotransmission in liver failure

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Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate

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21 January 2018

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

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21 January 2018

Partial pressure of ammonia versus ammonia in hepatic encephalopathy.

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21 January 2018

Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension.

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Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

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Demonstration of neuron-glia transfer of precursors for GABA biosynthesis in a co-culture system of dissociated mouse cerebral cortex

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21 January 2018

Blood ammonia levels and hepatic encephalopathy

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21 January 2018

[1-13C]glucose metabolism in brain cells: isotopomer analysis of glutamine from cerebellar astrocytes and glutamate from granule cells.

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21 January 2018

Ammonia-induced production of free radicals in primary cultures of rat astrocytes

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Astroglial dysfunction in hepatic encephalopathy

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Fine structural localization of glutamine synthetase in astrocytes of rat brain

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Mechanisms of ammonia-induced astrocyte swelling

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Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis

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The relative significance of CO2-fixing enzymes in the metabolism of rat brain

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Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine

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Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes

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Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia

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In vitro and in vivo effects of ammonia on glucose metabolism in the astrocytes of rat cerebral cortex

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Response of rat cerebral glycolytic enzymes to hyperammonemic states

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GABA: homeostatic and pharmacological aspects

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Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

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Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats

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Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

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Pyruvate carboxylase activity in primary cultures of astrocytes and neurons

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Precursors of glutamic acid nitrogen in primary neuronal cultures: studies with 15N.

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The anaplerotic flux and ammonia detoxification in hepatic encephalopathy

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An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: further studies using NMR spectroscopy

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Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons

1 reference

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12 December 2020

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Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate

1 reference

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Hepatic encephalopathy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes: glutamate producers for neurons

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry and physiology of brain ammonia

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Quantitation of metabolic compartmentation in hyperammonemic brain by natural abundance 13C-NMR detection of 13C-15N coupling patterns and isotopic shifts

1 reference

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12 December 2020

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Structure of the blood-brain barrier and its role in the transport of amino acids

1 reference

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The metabolic fate of 13N-labeled ammonia in rat brain

1 reference

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Direct and indirect enhancement of GABAergic neurotransmission by ammonia: implications for the pathogenesis of hyperammonemic syndromes

1 reference

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The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

1 reference

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12 December 2020

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1 reference

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Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cells in vitro

1 reference

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1 reference

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Metabolic compartments in vivo. Ammonia and glutamic acid metabolism in brain and liver.

1 reference

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12 December 2020

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Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase

1 reference

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Protein measurement with the Folin phenol reagent

1 reference

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12 December 2020

based on heuristic

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Neuronal regulation of glutamate transporter subtype expression in astrocytes.

1 reference

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12 December 2020

based on heuristic

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Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

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Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia.

1 reference

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12 December 2020

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NMR spectroscopic study on the metabolic fate of [3-(13)C]alanine in astrocytes, neurons, and cocultures: implications for glia-neuron interactions in neurotransmitter metabolism

1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1007/S12640-010-9198-7

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

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