AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis. (Q48208455)

http://europepmc.org/abstract/MED/28658529

9 February 2018

title

AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis. (English)

1 reference

http://europepmc.org/abstract/MED/28658529

9 February 2018

1 reference

1

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2 June 2020

Csaba Szabó

4

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2 June 2020

Rosanna Di Paola

6

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2 June 2020

Salvatore Cuzzocrea

8

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2 June 2020

author name string

Grant R Stenton

2

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2 June 2020

Curtis Harwig

3

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2 June 2020

Emanuale Esposito

7

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2 June 2020

Lloyd F Mackenzie

9

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2 June 2020

Tiziana Genovese

5

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2 June 2020

language of work or name

English

0 references

publication date

28 June 2017

1 reference

http://europepmc.org/abstract/MED/28658529

9 February 2018

published in

British Journal of Pharmacology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28658529%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

174

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2 June 2020

page(s)

3045-3057

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2 June 2020

issue

18

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miR-155 in the progression of lung fibrosis in systemic sclerosis.

2 June 2020

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Dose-response Effects of Bleomycin on Inflammation and Pulmonary Fibrosis in Mice

29 September 2018

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Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease

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PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition

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Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo

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Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo

29 September 2018

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Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.

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Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.

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29 September 2018

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Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis

29 September 2018

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CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis

29 September 2018

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Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats.

29 September 2018

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Time course of bleomycin-induced lung fibrosis.

29 September 2018

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29 September 2018

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Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell-dependent

29 September 2018

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Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis

29 September 2018

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The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

29 September 2018

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Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

29 September 2018

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Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat.

29 September 2018

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Simple method of estimating severity of pulmonary fibrosis on a numerical scale

29 September 2018

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Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

29 September 2018

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Crossref

https://api.crossref.org/works/10.1111%2FBPH.13934

Predicting survival in newly diagnosed idiopathic pulmonary fibrosis: a 3-year prospective study

21 January 2018

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Crossref

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Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases

21 January 2018

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12 December 2020

Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium

1 reference

12 December 2020

Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP

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12 December 2020

Extracellular matrix and oscillatory mechanics of rat lung parenchyma in bleomycin-induced fibrosis.

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12 December 2020

Identifiers

DOI

10.1111/BPH.13934

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28658529%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28658529%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference