Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. (Q48215989)

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English	Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.	scientific article

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16 February 2020

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain (English)

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Sulayman D Dib-Hajj

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Jianying Huang

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Peng Zhao

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Jody Salomon

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Joost P H Drenth

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Stephen G Waxman

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1 September 2014

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Journal of Neuroscience

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12328-12340

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16 February 2020

Subclinical sensory neuropathy in late-onset restless legs syndrome

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12 December 2020

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Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein

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12 December 2020

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Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons

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12 December 2020

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Mechanisms of sodium channel inactivation

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A quantitative description of membrane current and its application to conduction and excitation in nerve

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12 December 2020

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Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

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12 December 2020

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Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia

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12 December 2020

based on heuristic

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Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

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12 December 2020

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SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels

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https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

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12 December 2020

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Sodium channel inactivation: molecular determinants and modulation

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12 December 2020

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The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

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12 December 2020

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Restless legs syndrome and polyneuropathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

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12 December 2020

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SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

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12 December 2020

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An SCN9A channelopathy causes congenital inability to experience pain

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https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Restless legs syndrome in diabetic neuropathy: a frequent manifestation of small fiber neuropathy.

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12 December 2020

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

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12 December 2020

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Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders

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https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Protein structure homology modeling using SWISS-MODEL workspace.

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https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Voltage-clamp and current-clamp recordings from mammalian DRG neurons

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12 December 2020

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Transfection of rat or mouse neurons by biolistics or electroporation

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12 December 2020

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Voltage-gated sodium channels: therapeutic targets for pain

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12 December 2020

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Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Na v 1.7 sodium channels

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12 December 2020

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Sequential formation of ion pairs during activation of a sodium channel voltage sensor

1 reference

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12 December 2020

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Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome.

1 reference

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12 December 2020

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Sodium channels in normal and pathological pain

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12 December 2020

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Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

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12 December 2020

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Molecular basis and structural insight of vascular K(ATP) channel gating by S-glutathionylation.

1 reference

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12 December 2020

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Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor

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https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Structural basis for gating charge movement in the voltage sensor of a sodium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Mechanism of voltage gating in potassium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Small fibre neuropathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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The response of Na(V)1.3 sodium channels to ramp stimuli: multiple components and mechanisms

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12 December 2020

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Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn

1 reference

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12 December 2020

based on heuristic

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Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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The Na(V)1.7 sodium channel: from molecule to man.

1 reference

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12 December 2020

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Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Painful Na-channelopathies: an expanding universe

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Treatment of restless legs syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.

1 reference

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12 December 2020

based on heuristic

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Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858H.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Inactivation of the sodium channel. I. Sodium current experiments

1 reference

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12 December 2020

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Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of peripheral axonal neuropathy in primary restless legs syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Restless legs syndrome in patients with polyneuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

based on heuristic

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Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.

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https://pubmed.ncbi.nlm.nih.gov/25209274

12 December 2020

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Identifiers

10.1523/JNEUROSCI.2773-14.2014

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16 February 2020

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16 February 2020

1 reference

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16 February 2020

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