PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors (Q48248659)

9 February 2018

title

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors (English)

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Gary Lewin

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Stefan G Lechner

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Stefan G Lechner

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Alexander Loewer

object named as

Alexander Loewer

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author name string

Katrin Schrenk-Siemens

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Hagen Wende

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Vincenzo Prato

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Kun Song

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Charlotte Rostock

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Jan Siemens

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language of work or name

English

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publication date

3 December 2014

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9 February 2018

published in

Nature Neuroscience

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volume

18

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issue

1

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page(s)

10-16

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The sensory neurons of touch

cites work

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Cellular and Molecular Mechanisms of Pain

21 January 2018

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Molecular interactions underlying the specification of sensory neurons

21 January 2018

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Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

21 January 2018

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Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

21 January 2018

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Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

21 January 2018

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Piezo proteins are pore-forming subunits of mechanically activated channels

21 January 2018

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Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

21 January 2018

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Piezo2 is required for Merkel-cell mechanotransduction

21 January 2018

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Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses

21 January 2018

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Specification and connectivity of neuronal subtypes in the sensory lineage.

21 January 2018

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Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia

21 January 2018

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Differentiation of neural lineage cells from human pluripotent stem cells

21 January 2018

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CHD7 cooperates with PBAF to control multipotent neural crest formation

21 January 2018

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Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation

21 January 2018

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Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling

21 January 2018

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A role for BDNF in mechanosensation

21 January 2018

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Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling

21 January 2018

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A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs

21 January 2018

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Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development

21 January 2018

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The transcription factor c-Maf controls touch receptor development and function.

21 January 2018

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KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.

21 January 2018

1 reference

Rapid single-step induction of functional neurons from human pluripotent stem cells

21 January 2018

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A high-efficiency system for the generation and study of human induced pluripotent stem cells

21 January 2018

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Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

21 January 2018

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Single-cell analysis of sodium channel expression in dorsal root ganglion neurons

21 January 2018

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

21 January 2018

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The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

21 January 2018

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Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

21 January 2018

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Genetic engineering of human pluripotent cells using TALE nucleases

21 January 2018

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Cas9 as a versatile tool for engineering biology

21 January 2018

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Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

21 January 2018

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Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.

21 January 2018

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The Sequence Alignment/Map format and SAMtools

21 January 2018

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Differential expression analysis for sequence count data

21 January 2018

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HTSeq--a Python framework to work with high-throughput sequencing data

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25469543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Somal action potential duration differs in identified primary afferents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25469543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.3894

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9 February 2018

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9 February 2018