MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. (Q48262198)

10 February 2018

title

MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. (English)

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10 February 2018

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Alain Roulet

1

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10 February 2018

Olivier Puel

2

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Stéphane Gesta

3

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Jean-François Lepage

4

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Marlene Drag

5

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Mark Soll

6

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Michel Alvinerie

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Thierry Pineau

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language of work or name

English

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publication date

1 January 2003

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10 February 2018

European Journal of Pharmacology

published in

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10 February 2018

volume

460

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issue

2-3

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page(s)

85-91

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10 February 2018

Ivermectin, an antiparasitic agent

cites work

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The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor.

7 January 2021

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A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle

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P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity

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7 January 2021

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Modes of action of anthelmintic drugs

7 January 2021

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Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

7 January 2021

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Ivermectin excretion by isolated functionally intact brain endothelial capillaries

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Reversal of P-glycoprotein-associated multidrug resistance by ivermectin

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

7 January 2021

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

7 January 2021

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Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

7 January 2021

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P-glycoprotein-mediated efflux transport of anticancer drugs at the blood-brain barrier.

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Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism.

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10.1016/S0014-2999(02)02955-2

7 January 2021

Identifiers

DOI

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10 February 2018

PubMed ID

12559367

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10 February 2018