Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons. (Q48297809)

10 February 2018

title

Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons. (English)

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10 February 2018

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Haripriya Vittal Rao

1

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Lakshmi Thirumangalakudi

series ordinal

2

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10 February 2018

Paula Desmond

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3

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10 February 2018

Paula Grammas

series ordinal

4

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language of work or name

English

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publication date

24 January 2007

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Journal of Neurochemistry

published in

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volume

101

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issue

2

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10 February 2018

page(s)

498-505

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10 February 2018

Thrombin accumulation in brains of patients with Alzheimer's disease

cites work

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Bim is a direct target of a neuronal E2F-dependent apoptotic pathway.

21 January 2018

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Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis.

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Thrombin in ischemic neuronal death

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Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.

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Divide and die: cell cycle events as triggers of nerve cell death.

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Protein-protein interactions in Cdk5 regulation and function

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Thrombin, a mediator of neurotoxicity and memory impairment

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

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Mechanisms of cell death in primary cortical neurons and PC12 cells

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Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brain

21 January 2018

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Expression of cell cycle-related genes during neuronal apoptosis: is there a distinct pattern?

21 January 2018

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Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons

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Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis

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Utilization of luminescent technology to develop a kinase assay: Cdk4 as a model system

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

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Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease

21 January 2018

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Persistent Activation of CDK4 during Neuronal Differentiation of Rat Pheochromocytoma PC12 Cells

21 January 2018

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10.1111/J.1471-4159.2006.04389.X

21 January 2018

Identifiers

DOI

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10 February 2018

PubMed ID

17254021

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10 February 2018