Bone morphogenetic protein receptor type 1B (Q4835993)

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mammalian protein found in Homo sapiens

ALK-6
BMPR1B
activin receptor-like kinase 6
CDw293
BMP type-1B receptor
bone morphogenetic protein receptor, type IB
BMPR-1B
ALK6
bone morphogenetic protein receptor type-1B
serine/threonine receptor kinase

Language	Label	Description	Also known as
English	Bone morphogenetic protein receptor type 1B	mammalian protein found in Homo sapiens	ALK-6 BMPR1B activin receptor-like kinase 6 CDw293 BMP type-1B receptor bone morphogenetic protein receptor, type IB BMPR-1B ALK6 bone morphogenetic protein receptor type-1B serine/threonine receptor kinase

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

TGFβ superfamily receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

activin types I and II receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

transmembrane receptor protein serine/threonine kinase activity

determination method

3 references

8 April 2019

Chromosomal localization of three human genes encoding bone morphogenetic protein receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

transforming growth factor beta receptor activity, type I

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00238&geneProductId=UniProtKB:O00238

determination method

protein binding

determination method

8 references

8 April 2019

Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

determination method

1 reference

24 April 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00238&geneProductId=UniProtKB:O00238

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

transforming growth factor beta-activated receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

growth factor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

HFE-transferrin receptor complex

determination method

1 reference

8 April 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

determination method

2 references

receptor complex

determination method

1 reference

24 April 2018

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00238&geneProductId=UniProtKB:O00238

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

integral component of plasma membrane

determination method

1 reference

24 April 2018

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00238&geneProductId=UniProtKB:O00238

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

biological process

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

skeletal system development

determination method

1 reference

8 April 2019

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

limb morphogenesis

determination method

1 reference

8 April 2019

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

chondrocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

positive regulation of bone mineralization

determination method

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

chondrocyte development

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

cellular response to BMP stimulus

determination method

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

BMP signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Chromosomal localization of three human genes encoding bone morphogenetic protein receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

negative regulation of chondrocyte proliferation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

cartilage development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

positive regulation of osteoblast differentiation

determination method

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

retina development in camera-type eye

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

positive regulation of cartilage development

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

positive regulation of chondrocyte differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

positive regulation of cell differentiation

determination method

1 reference

8 April 2019

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

camera-type eye development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

inflammatory response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

dorsal/ventral pattern formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

endochondral bone morphogenesis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

proteoglycan biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

retinal ganglion cell axon guidance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

cellular response to growth factor stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

pattern specification process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00238

determination method

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

activin types I and II receptor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00238

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264568

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264568

ENSP00000378389

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378389

ENSP00000401907

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401907

ENSP00000421671

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421671

ENSP00000425444

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425444

ENSP00000426617

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426617

ENSP00000421144

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421144

ENSP00000500035

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500035

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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