PrP(C) homodimerization stimulates the production of PrPC cleaved fragments PrPN1 and PrPC1. (Q48369828)

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13 February 2020

title

PrP(C) homodimerization stimulates the production of PrPC cleaved fragments PrPN1 and PrPC1 (English)

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3

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author name string

Maxime Béland

series ordinal

1

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Julie Motard

series ordinal

2

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Xavier Roucou

series ordinal

4

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13 February 2020

language of work or name

English

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publication date

1 September 2012

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13 February 2020

published in

Journal of Neuroscience

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volume

32

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issue

38

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page(s)

13255-13263

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describes a project that uses

13 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

A monomer-dimer equilibrium of a cellular prion protein (PrPC) not observed with recombinant PrP.

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12 December 2020

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

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NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

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Neuroprotective functions of prion protein

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Roles of G-protein-coupled receptor dimerization

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Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.

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Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.

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ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

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The N-terminal cleavage of cellular prion protein in the human brain.

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Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways.

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Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx

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The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.

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12 December 2020

Aggregation of cellular prion protein is initiated by proximity-induced dimerization

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12 December 2020

Physiology of the prion protein

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Stress-protective signalling of prion protein is corrupted by scrapie prions

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alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts

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12 December 2020

The prion protein knockout mouse: a phenotype under challenge

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Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

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Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production

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ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices

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Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

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Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage

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The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

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12 December 2020

Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection

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12 December 2020

Axonal prion protein is required for peripheral myelin maintenance

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12 December 2020

Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations

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12 December 2020

Understanding the neurospecificity of Prion protein signaling

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12 December 2020

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

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12 December 2020

Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.

1 reference

12 December 2020

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

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12 December 2020

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

1 reference

12 December 2020

α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death

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12 December 2020

Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle

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12 December 2020

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

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12 December 2020

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

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12 December 2020

Truncated forms of the human prion protein in normal brain and in prion diseases.

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12 December 2020

Controlling signal transduction with synthetic ligands

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12 December 2020

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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12 December 2020

A 60-kDa prion protein (PrP) with properties of both the normal and scrapie-associated forms of PrP.

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12 December 2020

Mice devoid of PrP are resistant to scrapie

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12 December 2020

Normal host prion protein necessary for scrapie-induced neurotoxicity.

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12 December 2020

A vector for expressing foreign genes in the brains and hearts of transgenic mice

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12 December 2020

Prion Protein Biology

1 reference

12 December 2020

10.1523/JNEUROSCI.2236-12.2012

Identifiers

DOI

1 reference

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PubMed publication ID

22993441

1 reference