Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I. (Q48374375)

11 February 2018

title

Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I. (English)

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11 February 2018

7

Christer Halldin

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H Umesha Shetty

1

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Sami S Zoghbi

2

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Jeih-San Liow

3

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Masanori Ichise

4

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Jinsoo Hong

5

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John L Musachio

6

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Jurgen Seidel

8

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Robert B Innis

9

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Victor W Pike

10

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publication date

10 November 2006

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11 February 2018

number of pages

12

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European Journal of Nuclear Medicine and Molecular Imaging

inferred from page(s)

published in

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volume

34

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issue

5

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page(s)

667-678

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https://scigraph.springernature.com/pub.10.1007/s00259-006-0277-1

exact match

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Characterization of a phenobarbital-inducible cytochrome P-450, NADPH-cytochrome P-450 reductase and reconstituted cytochrome P-450 mono-oxygenase system from rat brain. Evidence for constitutive presence in rat and human brain

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[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder

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12 December 2020

Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging.

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Quantitative analyses of regional [11C]PE2I binding to the dopamine transporter in the human brain: a PET study

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Metabolism and covalent binding of [14C]toluene by human and rat liver microsomal fractions and liver slices

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Lower dopamine transporter binding potential in striatum during depression

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Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease

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Drug entry into the brain

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Exploration of the dopamine transporter: in vitro and in vivo characterization of a high-affinity and high-specificity iodinated tropane derivative (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-m ethylph enyl)nortropane (PE2I).

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Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography

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Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity

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PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements.

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Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters.

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Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia

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[(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain

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N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters.

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Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.

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Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease.

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Progression in Parkinson's disease: a positron emission tomography study with a dopamine transporter ligand [18F]CFT.

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Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT.

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18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters

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12 December 2020

10.1007/S00259-006-0277-1

Identifiers

DOI

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11 February 2018

PubMed ID

17096093

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11 February 2018