Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. (Q48375426)

11 February 2018

title

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. (English)

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11 February 2018

author name string

Pan H

1

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11 February 2018

Yin C

2

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11 February 2018

Dyson NJ

3

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11 February 2018

Harlow E

4

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11 February 2018

Yamasaki L

5

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11 February 2018

Van Dyke T

6

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11 February 2018

publication date

1 September 1998

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11 February 2018

published in

Molecular Cell

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11 February 2018

volume

2

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11 February 2018

issue

3

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11 February 2018

page(s)

283-292

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11 February 2018

Transcriptional control by E2F.

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Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.

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E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo

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Lymphotropic papovavirus early region is specifically regulated transgenic mice and efficiently induces neoplasia

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

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Distinct roles for E2F proteins in cell growth control and apoptosis

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Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.

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E2F-1 functions in mice to promote apoptosis and suppress proliferation

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The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice

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Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

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E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis

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E2F-5, a new E2F family member that interacts with p130 in vivo

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Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression

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Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F.

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Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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Oncogenic capacity of the E2F1 gene

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E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

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Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

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The retinoblastoma protein binds to a family of E2F transcription factors

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7 January 2021

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

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7 January 2021

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

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A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

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Tumor suppressor genes

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

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7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

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7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

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Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen

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7 January 2021

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle

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7 January 2021

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

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7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

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7 January 2021

Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis

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The ins and outs of RB: coupling gene expression to the cell cycle clock

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7 January 2021

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p53-dependent apoptosis suppresses tumor growth and progression in vivo

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7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

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7 January 2021

Tumor suppressor genes

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7 January 2021

The retinoblastoma protein and cell cycle control

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7 January 2021

Mechanism of active transcriptional repression by the retinoblastoma protein

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7 January 2021

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

Multiple members of the E2F transcription factor family are the products of oncogenes

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7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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7 January 2021

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

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7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

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7 January 2021

pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.

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7 January 2021

10.1016/S1097-2765(00)80273-7

Identifiers

DOI

1 reference

11 February 2018

PubMed ID

9774967

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11 February 2018