P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice. (Q48378208)

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31 October 2019

title

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice (English)

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31 October 2019

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2

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31 October 2019

Elizabeth C de Lange

4

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31 October 2019

Dirk-Jan van den Berg

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31 October 2019

author name string

Graeme J. Sills

1

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31 October 2019

Elaine Butler

3

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31 October 2019

Martin J. Brodie

6

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31 October 2019

publication date

1 October 2002

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31 October 2019

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31 October 2019

volume

3

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31 October 2019

issue

5

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31 October 2019

page(s)

427-432

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Early identification of refractory epilepsy

31 October 2019

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats

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P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

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The functional role of P-glycoprotein in the blood-brain barrier

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt

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7 January 2021

Carbamazepine is not a substrate for P-glycoprotein

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7 January 2021

The P-glycoprotein efflux pump: how does it transport drugs?

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7 January 2021

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Identifiers

DOI

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31 October 2019

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