BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice (Q48379491)

11 February 2018

title

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice (English)

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11 February 2018

17

Paul S Aisen

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Kouhei Nishitomi

1

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Gaku Sakaguchi

2

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Yuko Horikoshi

3

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Audrey J Gray

4

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Masahiro Maeda

5

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Chiho Hirata-Fukae

6

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Amanda G Becker

7

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Motoko Hosono

8

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Isako Sakaguchi

9

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S Sakura Minami

10

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Yoshihiro Nakajima

11

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Hui-Fang Li

12

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Chie Takeyama

13

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Tsuyoshi Kihara

14

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Akinobu Ota

15

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Philip C Wong

16

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Akira Kato

18

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Noriaki Kinoshita

19

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Yasuji Matsuoka

20

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language of work or name

English

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publication date

2 November 2006

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11 February 2018

Journal of Neurochemistry

published in

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11 February 2018

volume

99

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issue

6

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page(s)

1555-1563

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11 February 2018

The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors

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Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

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Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

21 January 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980-1990 prevalence findings. The EURODEM-Prevalence Research Group.

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The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

21 January 2018

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

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Conformationally biased P3 amide replacements of beta-secretase inhibitors

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Employing a superior BACE1 cleavage sequence to probe cellular APP processing

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

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10.1111/J.1471-4159.2006.04178.X

21 January 2018

Identifiers

DOI

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11 February 2018

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11 February 2018