Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline. (Q48379621)

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scientific article published on 28 January 2015

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English	Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline.	scientific article published on 28 January 2015

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scholarly article

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline. (English)

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

1 reference

based on heuristic

inferred from title

Victor A. Gault

1

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

3

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

author name string

R Lennox

2

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

publication date

28 January 2015

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

Diabetes, Obesity and Metabolism

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

17

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

4

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

403-413

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

Glucose levels and risk of dementia

1 reference

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21 January 2018

High-fat diets, insulin resistance and declining cognitive function

1 reference

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21 January 2018

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.

1 reference

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21 January 2018

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet.

1 reference

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21 January 2018

Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone.

1 reference

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21 January 2018

Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease

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21 January 2018

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model

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21 January 2018

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

1 reference

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21 January 2018

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

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21 January 2018

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

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21 January 2018

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

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21 January 2018

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4

1 reference

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21 January 2018

The glucagon-like peptides: a double-edged therapeutic sword?

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21 January 2018

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system.

1 reference

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21 January 2018

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.

1 reference

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21 January 2018

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

1 reference

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21 January 2018

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

1 reference

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21 January 2018

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

1 reference

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21 January 2018

Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes

1 reference

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21 January 2018

Sitagliptin: Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Safety of dipeptidyl peptidase 4 inhibitors: a perspective review

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Incretins: what is known, new and controversial in 2013?

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Neuroprotective properties of GLP-1: theoretical and practical applications

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats.

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections

1 reference

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21 January 2018

Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice.

1 reference

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21 January 2018

GLP-1 and exendin-4 transiently enhance GABAA receptor-mediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons.

1 reference

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21 January 2018

New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?

1 reference

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21 January 2018

Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.

1 reference

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21 January 2018

Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice

1 reference

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21 January 2018

VEGF links hippocampal activity with neurogenesis, learning and memory

1 reference

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21 January 2018

Dipeptidyl peptidase IV inhibition activates CREB and improves islet vascularization through VEGF-A/VEGFR-2 signaling pathway

1 reference

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21 January 2018

mTOR signaling: at the crossroads of plasticity, memory and disease

1 reference

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21 January 2018

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

1 reference

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21 January 2018

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

1 reference

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21 January 2018

SIRT1 is essential for normal cognitive function and synaptic plasticity

1 reference

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21 January 2018

Sirtuins in cognitive ageing and Alzheimer's disease

1 reference

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21 January 2018

Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis

1 reference

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21 January 2018

Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression1This work was supported by a grant from the Crohn's and Colitis Foundation of America.1

1 reference

https://api.crossref.org/works/10.1111%2FDOM.12432

21 January 2018

Identifiers

10.1111/DOM.12432

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/25580570

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