Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. (Q48380188)

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5 December 2019

title

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain (English)

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5 December 2019

author name string

S A Frautschy

1

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D L Horn

2

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J J Sigel

3

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M E Harris-White

4

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J J Mendoza

5

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F Yang

6

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T C Saido

7

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G M Cole

8

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language of work or name

English

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publication date

1 October 1998

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5 December 2019

published in

Journal of Neuroscience

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volume

18

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issue

20

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5 December 2019

page(s)

8311-8321

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

5 December 2019

cites work

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Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

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Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

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Enhanced aggregation of beta-amyloid-containing peptides by extracellular matrix and their degradation by the 68 kDa serine protease prepared from human brain.

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beta-Amyloid peptide produced in vitro is degraded by proteinases released by cultured cells

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Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

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Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

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Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid

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12 December 2020

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

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12 December 2020

Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease.

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12 December 2020

beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin.

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12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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12 December 2020

An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

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12 December 2020

The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.

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12 December 2020

Monoclonal antibody to the C-terminus of beta-amyloid.

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12 December 2020

Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.

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12 December 2020

Microglial response to transient focal cerebral ischemia: an immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody

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Scavenging of Alzheimer's amyloid beta-protein by microglia in culture.

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12 December 2020

Solvent effects on beta protein toxicity in vivo

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease.

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12 December 2020

A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease.

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12 December 2020

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

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12 December 2020

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

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12 December 2020

Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition

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12 December 2020

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

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12 December 2020

Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4.

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12 December 2020

Rapid cellular uptake of Alzheimer amyloid betaA4 peptide by cultured human neuroblastoma cells

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12 December 2020

Accumulation of amyloid precursor fragment in Alzheimer plaques

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

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12 December 2020

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

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12 December 2020

Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein.

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12 December 2020

Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.

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12 December 2020

Lysosome instability in aged rat brain

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12 December 2020

Degradation of Alzheimer's beta-amyloid protein by human cathepsin D.

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12 December 2020

Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins

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12 December 2020

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

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12 December 2020

Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

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12 December 2020

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12 December 2020

Lack of long-term effects after beta-amyloid protein injections in rat brain

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12 December 2020

An Endosomal‐Lysosomal Pathway for Degradation of Amyloid Precursor Protein a

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12 December 2020

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

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12 December 2020

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

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12 December 2020

10.1523/JNEUROSCI.18-20-08311.1998

Identifiers

DOI

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