Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway (Q48393379)

11 February 2018

title

Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway (English)

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11 February 2018

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Rui-Qin Yao

1

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11 February 2018

Da-Shi Qi

2

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11 February 2018

Hong-Li Yu

3

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11 February 2018

Jing Liu

4

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11 February 2018

Li-Hua Yang

5

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11 February 2018

Xiu-Xiang Wu

6

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11 February 2018

publication date

31 August 2012

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11 February 2018

published in

Neurochemical Research

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11 February 2018

volume

37

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11 February 2018

issue

12

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11 February 2018

page(s)

2777-2786

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11 February 2018

The large and growing burden of stroke

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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Mitochondria and apoptosis

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways

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Trk receptors: mediators of neurotrophin action

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Regulation of cell death protease caspase-9 by phosphorylation

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Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia

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In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway

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Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats.

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Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

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Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice

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Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of the PI3K/Akt signaling pathway

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Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats.

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Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia

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Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats

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Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation

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Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats

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Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

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Predictors of in-hospital mortality in patients with acute ischemic stroke treated with thrombolytic therapy

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12 December 2020

Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion

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Cerebral ischemia induced apoptosis and necrosis in normal and diabetic rats

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BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway

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10.1007/S11064-012-0871-5

Identifiers

DOI

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11 February 2018

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11 February 2018