The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs (Q48453986)

11 February 2018

title

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs (English)

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3

Mandelkow EM

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11 February 2018

author name string

N. Gustke

1

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B. Steiner

2

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E. M. Mandelkow

3

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J. Biernat

4

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H. E. Meyer

5

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M. Goedert

6

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E. Mandelkow

7

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language of work or name

English

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publication date

1 July 1992

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11 February 2018

28 July 1992

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1644173

full work available at URL

20 October 2022

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2892%2980767-B

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https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(92)80767-B

20 October 2022

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http://onlinelibrary.wiley.com/wol1/doi/10.1016/0014-5793(92)80767-B/fullpdf

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11 February 2018

volume

307

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11 February 2018

issue

2

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11 February 2018

page(s)

199-205

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11 February 2018

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

21 January 2018

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Tau protein binds to microtubules through a flexible array of distributed weak sites

21 January 2018

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Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

21 January 2018

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

21 January 2018

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

21 January 2018

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

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Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation

21 January 2018

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Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

21 January 2018

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Tau proteins: the molecular structure and mode of binding on microtubules

21 January 2018

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A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau

21 January 2018

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A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

21 January 2018

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Epitopes that span the tau molecule are shared with paired helical filaments.

21 January 2018

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Tau protein and Alzheimer's disease

21 January 2018

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Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

21 January 2018

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The primary structure and heterogeneity of tau protein from mouse brain

21 January 2018

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

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Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

21 January 2018

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Tubulin domains probed by limited proteolysis and subunit-specific antibodies.

21 January 2018

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Use of T7 RNA polymerase to direct expression of cloned genes

21 January 2018

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

21 January 2018

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Location and sequence characterization of the major phosphorylation sites of the high molecular mass neurofilament proteins M and H

21 January 2018

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Determination and location of phosphoserine in proteins and peptides by conversion to S-ethylcysteine

21 January 2018

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The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

21 January 2018

3

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Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

20 October 2022

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Identifiers

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11 February 2018

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11 February 2018