Novel anti-brain tumor cytotoxins specific for cancer cells (Q48466719)

11 February 2018

title

Novel anti-brain tumor cytotoxins specific for cancer cells (English)

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11 February 2018

author name string

Debinski W

1

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11 February 2018

Gibo DM

2

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11 February 2018

Obiri NI

3

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11 February 2018

Kealiher A

4

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11 February 2018

Puri RK

5

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11 February 2018

publication date

1 May 1998

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11 February 2018

published in

Nature Biotechnology

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11 February 2018

volume

16

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11 February 2018

issue

5

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11 February 2018

page(s)

449-453

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11 February 2018

Receptor for interleukin (IL) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells.

cites work

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Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.

21 January 2018

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Immunotoxins for central nervous system malignancy

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The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor

21 January 2018

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Characterization and comparison of the interleukin 13 receptor with the interleukin 4 receptor on several cell types

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Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

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IL-4 receptor complexes containing or lacking the gamma C chain are inhibited by an overlapping set of antagonistic IL-4 mutant proteins

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Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain

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Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells

21 January 2018

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Intratumoral infusion of the monoclonal antibody, mAb 425, against the epidermal-growth-factor receptor in patients with advanced malignant glioma

21 January 2018

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Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

21 January 2018

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A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4

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7 January 2021

Recombinant toxins as novel therapeutic agents

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Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa

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7 January 2021

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

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7 January 2021

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,

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7 January 2021

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction

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7 January 2021

Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency

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7 January 2021

Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.

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7 January 2021

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily

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7 January 2021

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

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7 January 2021

An antagonistic mutant of interleukin-4 fails to recruit gamma c into the receptor complex. Characterization by specific crosslinking

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7 January 2021

A circularly permuted recombinant interleukin 4 toxin with increased activity

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7 January 2021

Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice

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7 January 2021

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

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7 January 2021

Analysis of longitudinal data: random coefficient regression modelling

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7 January 2021

Identifiers

DOI

10.1038/NBT0598-449

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11 February 2018

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11 February 2018