Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. (Q48479768)

11 February 2018

title

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. (English)

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11 February 2018

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1

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11 February 2018

Wolfgang Wick

4

object named as

W Wick

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11 February 2018

Carlos F. Menck

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object named as

C F M Menck

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11 February 2018

author name string

L F Z Batista

2

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11 February 2018

S C Naumann

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11 February 2018

M Weller

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11 February 2018

B Kaina

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11 February 2018

language of work or name

English

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publication date

3 July 2006

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11 February 2018

published in

Oncogene

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11 February 2018

volume

26

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11 February 2018

page(s)

186-197

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11 February 2018

issue

2

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11 February 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209785

exact match

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Relationship between expression of O6-methylguanine-DNA methyltransferase, glutathione-S-transferase π in glioblastoma and the survival of the patients treated with nimustine hydrochloride: An immunohistochemical analysis

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Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells

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DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors

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Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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O6-methylguanine-DNA methyltransferase activity in human tumors

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Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

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The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

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Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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MGMT: its role in cancer aetiology and cancer therapeutics

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Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids

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Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

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MGMT gene silencing and benefit from temozolomide in glioblastoma

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O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

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Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

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Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

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Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

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Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

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DNA damage tolerance, mismatch repair and genome instability

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

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DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts

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O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy

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O6-alkylguanine DNA lesions trigger apoptosis

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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

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Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

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Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure

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Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

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Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

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7 January 2021

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209785

1 reference

11 February 2018

Dimensions Publication ID

1009706483

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Fatcat ID

release_zpsi6qdgtfhfnnyco6lgr3n5l4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zpsi6qdgtfhfnnyco6lgr3n5l4

24 November 2022

mapped directly with Wikidata item

PubMed ID

16819506

1 reference

11 February 2018