A novel approach to improve the function of FGF21. (Q48506046)

12 February 2018

title

A novel approach to improve the function of FGF21. (English)

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12 February 2018

author name string

Richard Smith

1

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12 February 2018

Amy Duguay

2

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12 February 2018

Jennifer Weiszmann

3

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12 February 2018

Shanaka Stanislaus

4

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12 February 2018

Ed Belouski

5

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12 February 2018

Ling Cai

6

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12 February 2018

Junming Yie

7

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12 February 2018

Jing Xu

8

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12 February 2018

Jamila Gupte

9

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12 February 2018

Xinle Wu

10

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12 February 2018

Yang Li

11

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12 February 2018

publication date

1 April 2013

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12 February 2018

published in

BioDrugs

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12 February 2018

volume

27

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12 February 2018

issue

2

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12 February 2018

page(s)

159-166

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12 February 2018

https://scigraph.springernature.com/pub.10.1007/s40259-013-0013-x

exact match

0 references

cites work

FGF-21 as a novel metabolic regulator

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Fibroblast growth factor 21 corrects obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

FGF21 as a therapeutic reagent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

An FGF1:FGF2 chimeric growth factor exhibits universal FGF receptor specificity, enhanced stability and augmented activity useful for epithelial proliferation and radioprotection.

21 January 2018

1 reference

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Regulation of fibroblast growth factor-23 signaling by klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Co-receptor requirements for fibroblast growth factor-19 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Different roles of N- and C- termini in the functional activity of FGF21

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

FGF21 N- and C-termini play different roles in receptor interaction and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

Therapeutic utilities of fibroblast growth factor 19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40259-013-0013-X

10.1007/S40259-013-0013-X

21 January 2018

Identifiers

DOI

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12 February 2018

PubMed ID

23456652

1 reference

12 February 2018